PS(18:1(9Z)/16:1(9Z))

Found 41 Sample Hits

m/z	Adducts	Species	Organ	Scanning	Sample
760.5121	[M+H]+ PPM:0.2	Bathymodiolus	epithelial host cells	MALDI (DHB)	MPIMM_039_QE_P_BP_CF_Bputeoserpentis_MALDI-FISH8_Sl14_s1_DHB_233x233_3um - MTBLS744 Resolution: 3μm, 233x234 Description
782.5034	[M+Na]+ PPM:11.7	Mus musculus	Lung	MALDI (DHB)	image5 - MTBLS2075 Resolution: 40μm, 163x183 Description Supplementary Figure S8. MALDI-MSI data of mouse lung tissue administered with D9-choline and U 13C-DPPC–containing Poractant alfa surfactant (labels administered 18 h prior to sacrifice). Ion images of (a) m/z 796.6856 ([U13C-DPPC+Na]+), (b) m/z 756.5154 [PC32:0+Na]+ and (c) m/z 765.6079 ([D9-PC32:0+Na]+). (d) Overlay image of [U13C-DPPC+Na]+ (red) and [D9-PC32:0+Na]+ (green). Parts per million (ppm) mass errors are indicated in parentheses. All images were visualised using totalion-current normalisation and using hotspot removal (high quantile = 99%). DPPC = PC16:0/16:0.
760.4992	[M+H]+ PPM:17.2	Macropus giganteus	Brain	MALDI (BPYN)	170321_kangaroobrain-dan3-pos_maxof50.0_med1 - 170321_kangaroobrain-dan3-pos_maxof50.0_med1 Resolution: 50μm, 81x50 Description Sample information Organism: Macropus giganteus (kangaroo) Organism part: Brain Condition: Wildtype Sample growth conditions: Wild
760.5151	[M+H]+ PPM:3.7	Homo sapiens	esophagus	DESI ()	LNTO22_1_3 - MTBLS385 Resolution: 75μm, 121x68 Description
760.5117	[M+H]+ PPM:0.8	Homo sapiens	esophagus	DESI ()	LNTO22_1_4 - MTBLS385 Resolution: 17μm, 82x80 Description
760.5139	[M+H]+ PPM:2.1	Homo sapiens	esophagus	DESI ()	LNTO29_16_2 - MTBLS385 Resolution: 17μm, 95x101 Description
760.513	[M+H]+ PPM:0.9	Homo sapiens	esophagus	DESI ()	TO42T - MTBLS385 Resolution: 17μm, 69x81 Description
760.5159	[M+H]+ PPM:4.8	Homo sapiens	esophagus	DESI ()	LNTO22_1_9 - MTBLS385 Resolution: 75μm, 89x74 Description
760.5118	[M+H]+ PPM:0.6	Mus musculus	Liver	MALDI (CHCA)	Salmonella_final_pos_recal - MTBLS2671 Resolution: 17μm, 691x430 Description A more complete and holistic view on host–microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, we developed a multimodal imaging approach combining histopathology with mass spectrometry imaging (MSI) and same section imaging mass cytometry (IMC) to study the effects of Salmonella Typhimurium infection in the liver of a mouse model using the S. Typhimurium strains SL3261 and SL1344. This approach enables correlation of tissue morphology and specific cell phenotypes with molecular images of tissue metabolism. IMC revealed a marked increase in immune cell markers and localization in immune aggregates in infected tissues. A correlative computational method (network analysis) was deployed to find metabolic features associated with infection and revealed metabolic clusters of acetyl carnitines, as well as phosphatidylcholine and phosphatidylethanolamine plasmalogen species, which could be associated with pro-inflammatory immune cell types. By developing an IMC marker for the detection of Salmonella LPS, we were further able to identify and characterize those cell types which contained S. Typhimurium. [dataset] Nicole Strittmatter. Holistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging, metabolights_dataset, V1; 2022. https://www.ebi.ac.uk/metabolights/MTBLS2671.
760.5136	[M+H]+ PPM:1.7	Homo sapiens	esophagus	DESI ()	LNTO30_8M_1 - MTBLS385 Resolution: 17μm, 69x54 Description
760.5131	[M+H]+ PPM:1.1	Homo sapiens	esophagus	DESI ()	TO39T - MTBLS385 Resolution: 17μm, 69x81 Description
760.5127	[M+H]+ PPM:0.5	Homo sapiens	colorectal adenocarcinoma	DESI ()	80TopL, 50TopR, 70BottomL, 60BottomR-profile - MTBLS415 Resolution: 17μm, 137x136 Description The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024).
760.5181	[M+H]+ PPM:7.6	Homo sapiens	colorectal adenocarcinoma	DESI ()	520TopL, 490TopR, 510BottomL, 500BottomR-profile - MTBLS415 Resolution: 17μm, 147x131 Description The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024).
760.5158	[M+H]+ PPM:4.6	Homo sapiens	colorectal adenocarcinoma	DESI ()	439TopL, 409TopR, 429BottomL, 419BottomR-profile - MTBLS415 Resolution: 17μm, 157x136 Description The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024).
777.5436	[M+NH4]+ PPM:6.1	Homo sapiens	colorectal adenocarcinoma	DESI ()	439TopL, 409TopR, 429BottomL, 419BottomR-profile - MTBLS415 Resolution: 17μm, 157x136 Description The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024).
760.5077	[M+H]+ PPM:6	Homo sapiens	NA	DESI ()	160TopL,130TopR,150BottomL,140BottomR-profile - MTBLS415 Resolution: 17μm, 142x136 Description
760.5138	[M+H]+ PPM:2	Homo sapiens	esophagus	DESI ()	LNTO29_16_3 - MTBLS385 Resolution: 17μm, 108x107 Description
760.515	[M+H]+ PPM:3.6	Homo sapiens	esophagus	DESI ()	LNTO26_7_1 - MTBLS385 Resolution: 17μm, 75x74 Description
760.5157	[M+H]+ PPM:4.5	Homo sapiens	esophagus	DESI ()	LNTO26_7_2 - MTBLS385 Resolution: 17μm, 135x101 Description
760.5147	[M+H]+ PPM:3.2	Homo sapiens	esophagus	DESI ()	LNTO26_7_3 - MTBLS385 Resolution: 75μm, 82x88 Description
760.5136	[M+H]+ PPM:1.7	Homo sapiens	esophagus	DESI ()	TO31T - MTBLS385 Resolution: 75μm, 56x54 Description
760.5151	[M+H]+ PPM:3.7	Homo sapiens	esophagus	DESI ()	TO29T - MTBLS385 Resolution: 75μm, 56x48 Description
760.5135	[M+H]+ PPM:1.6	Homo sapiens	esophagus	DESI ()	TO41T - MTBLS385 Resolution: 75μm, 69x43 Description
760.5139	[M+H]+ PPM:2.1	Homo sapiens	esophagus	DESI ()	LNTO30_8M_2 - MTBLS385 Resolution: 75μm, 108x68 Description
760.5137	[M+H]+ PPM:1.9	Homo sapiens	esophagus	DESI ()	LNTO30_8M_3 - MTBLS385 Resolution: 75μm, 69x54 Description
760.5144	[M+H]+ PPM:2.8	Homo sapiens	esophagus	DESI ()	LNTO30_8M_4 - MTBLS385 Resolution: 75μm, 62x48 Description
760.514	[M+H]+ PPM:2.3	Homo sapiens	esophagus	DESI ()	LNTO30_8M_5 - MTBLS385 Resolution: 75μm, 56x54 Description
760.514	[M+H]+ PPM:2.3	Homo sapiens	esophagus	DESI ()	LNTO30_17_2 - MTBLS385 Resolution: 75μm, 82x54 Description
760.5152	[M+H]+ PPM:3.8	Homo sapiens	esophagus	DESI ()	LNTO22_1_5 - MTBLS385 Resolution: 75μm, 135x94 Description
760.5154	[M+H]+ PPM:4.1	Homo sapiens	esophagus	DESI ()	LNTO22_1_7 - MTBLS385 Resolution: 75μm, 69x54 Description
760.5148	[M+H]+ PPM:3.3	Homo sapiens	esophagus	DESI ()	LNTO22_1_8 - MTBLS385 Resolution: 75μm, 69x61 Description
760.5144	[M+H]+ PPM:2.8	Homo sapiens	esophagus	DESI ()	LNTO22_2_1 - MTBLS385 Resolution: 75μm, 89x88 Description
760.5152	[M+H]+ PPM:3.8	Homo sapiens	esophagus	DESI ()	LNTO22_2_2 - MTBLS385 Resolution: 75μm, 135x94 Description
760.5149	[M+H]+ PPM:3.4	Homo sapiens	esophagus	DESI ()	LNTO26_16_1 - MTBLS385 Resolution: 75μm, 95x88 Description
760.514	[M+H]+ PPM:2.3	Homo sapiens	esophagus	DESI ()	LNTO29_18_2 - MTBLS385 Resolution: 75μm, 62x68 Description
760.5141	[M+H]+ PPM:2.4	Homo sapiens	esophagus	DESI ()	LNTO30_7_1 - MTBLS385 Resolution: 75μm, 69x68 Description
760.5137	[M+H]+ PPM:1.9	Homo sapiens	esophagus	DESI ()	LNTO30_7_2 - MTBLS385 Resolution: 75μm, 82x68 Description
760.5134	[M+H]+ PPM:1.5	Homo sapiens	colorectal adenocarcinoma	DESI ()	240TopL, 210TopR, 230BottomL, 220BottomR-centroid - MTBLS176 Resolution: 50μm, 142x141 Description
760.5141	[M+H]+ PPM:2.4	Homo sapiens	colorectal adenocarcinoma	DESI ()	200TopL, 170TopR, 190BottomL, 180BottomR-centroid - MTBLS176 Resolution: 50μm, 132x126 Description
760.5133	[M+H]+ PPM:1.3	Homo sapiens	colorectal adenocarcinoma	DESI ()	160TopL,130TopR,150BottomL,140BottomR-centroid - MTBLS176 Resolution: 50μm, 142x136 Description
760.5138	[M+H]+ PPM:2	Homo sapiens	colorectal adenocarcinoma	DESI ()	120TopL, 90TopR, 110BottomL, 100BottomR-centroid - MTBLS176 Resolution: 50μm, 132x136 Description

PS(18:1(9Z)/16:1(9Z)) is a phosphatidylserine (PS or GPSer). It is a glycerophospholipid in which a phosphorylserine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphoserines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PS(18:1(9Z)/16:1(9Z)), in particular, consists of one chain of oleic acid at the C-1 position and one chain of palmitoleic acid at the C-2 position. The oleic acid moiety is derived from vegetable oils, especially olive and canola oil, while the palmitoleic acid moiety is derived from animal fats and vegetable oils. Phosphatidylserine or 1,2-diacyl-sn-glycero-3-phospho-L-serine is distributed widely among animals, plants and microorganisms. It is usually less than 10\\% of the total phospholipids, the greatest concentration being in myelin from brain tissue. However, it may comprise 10 to 20 mol\\% of the total phospholipid in the plasma membrane and endoplasmic reticulum of the cell. Phosphatidylserine is an acidic (anionic) phospholipid with three ionizable groups, i.e. the phosphate moiety, the amino group and the carboxyl function. As with other acidic lipids, it exists in nature in salt form, but it has a high propensity to chelate to calcium via the charged oxygen atoms of both the carboxyl and phosphate moieties, modifying the conformation of the polar head group. This interaction may be of considerable relevance to the biological function of phosphatidylserine, especially during bone formation for example. As phosphatidylserine is located entirely on the inner monolayer surface of the plasma membrane (and of other cellular membranes) and it is the most abundant anionic phospholipids. Therefore phosphatidylseriine may make the largest contribution to interfacial effects in membranes involving non-specific electrostatic interactions. This normal distribution is disturbed during platelet activation and cellular apoptosis. In human plasma, 1-stearoyl-2-oleoyl and 1-stearoyl-2-arachidonoyl species predominate, but in brain (especially grey matter), retina and many other tissues 1-stearoyl-2-docosahexaenoyl species are very abundant. Indeed, the ratio of n-3 to n-6 fatty acids in brain phosphatidylserine is very much higher than in most other lipids. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. Phosphatidylserines typically carry a net charge of -1 at physiological pH. They mostly have palmitic or stearic acid on carbon 1 and a long chain unsaturated fatty acid (e.g. 18:2, 20:4 and 22:6) on carbon 2. PS biosynthesis involves an exchange reaction of serine for ethanolamine in PE. PS(18:1(9Z)/16:1(9Z)) is a phosphatidylserine. It is a glycerophospholipid in which a phosphorylserine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, phosphatidylserines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 atoms. PS(18:1(9Z)/16:1(9Z)), in particular, consists of one 9Z-octadecenoyl chain to the C-1 atom, and one 9Z-hexadecenoyl to the C-2 atom. Phosphatidylserine or 1,2-diacyl-sn-glycero-3-phospho-L-serine is distributed widely among animals, plants and microorganisms. Phosphatidylserine is an acidic (anionic) phospholipid with three ionizable groups, i.e. the phosphate moiety, the amino group and the carboxyl function. As with other acidic lipids, it exists in nature in salt form, but it has a high propensity to chelate to calcium via the charged oxygen atoms of both the carboxyl and phosphate moieties, modifying the conformation of the polar head group. This interaction may be of considerable relevance to the biological function of phosphatidylserine. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. Phosphatidylserines typically carry a net charge of -1 at physiological pH. They mostly have palmitic or stearic acid on carbon 1 and a long chain unsaturated fatty acid (e.g. 18:2, 20:4 and 22:6) on carbon 2. PS biosynthesis involves an exchange reaction of serine for ethanolamine in PE.