Etidronic acid
                        Formula: C2H8O7P2 (205.9745)
                        
                        Chinese Name:  羟基乙叉二膦酸
                        BioDeep ID: BioDeep_00000003376 
                        ( View LC/MS Profile)
                        SMILES:  CC(O)(P(O)(O)=O)P(O)(O)=O
                    
Found 25 Sample Hits
| m/z | Adducts | Species | Organ | Scanning | Sample | |
|---|---|---|---|---|---|---|
| 206.979 | [M+H]+PPM:13.5 | 
                                    Marker Pen | NA | DESI (None) | 
                                        3ul_0.8Mpa_RAW_20241016-PAPER PNMK - MEMI_testResolution: 30μm, 315x42
                                             By writing the four English letters “PNMK” on white paper with a marker pen, and then scanning with a DESI ion source to obtain the scanning result. The signal of the chemical substances on the marker pen used appears on the channel with an m/z value of   | 
                                    
                                        
                                             | 
                                
| 205.9969 | [M-H2O+NH4]+PPM:4.3 | 
                                    Mus musculus | Kidney | MALDI (CHCA) | 
                                        FULL_MS_centriod_CHCA_20210819 - FULL_MS_centriod_CHCA_20210819Resolution: 17μm, 638x437
                                             AP-MALDI instrument demo test, mass spectrum scan in centroid mode.  | 
                                    
                                        
                                             | 
                                
| 205.9981 | [M-H2O+NH4]+PPM:1.5 | 
                                    Plant | Root | MALDI (DHB) | 
                                        MPIMM_035_QE_P_PO_6pm - MPIMM_035_QE_P_PO_6pmResolution: 30μm, 165x170
                                              | 
                                    
                                        
                                             | 
                                
| 170.9606 | [M+H-2H2O]+PPM:0.4 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        20190614_MS1_A19r-20 - MTBLS1746Resolution: 17μm, 262x276
                                             Seagrasses are one of the most efficient natural sinks of carbon dioxide (CO2) on Earth. Despite covering less than 0.1% of coastal regions, they have the capacity to bury up to 10% of marine organic matter and can bury the same amount of carbon 35 times faster than tropical rainforests. On land, the soil’s ability to sequestrate carbon is intimately linked to microbial metabolism. Despite the growing attention to the link between plant production, microbial communities, and the carbon cycle in terrestrial ecosystems, these processes remain enigmatic in the sea. Here, we show that seagrasses excrete organic sugars, namely in the form of sucrose, into their rhizospheres. Surprisingly, the microbial communities living underneath meadows do not fully use this sugar stock in their metabolism. Instead, sucrose piles up in the sediments to mM concentrations underneath multiple types of seagrass meadows. Sediment incubation experiments show that microbial communities living underneath a meadow use sucrose at low metabolic rates. Our metagenomic analyses revealed that the distinct community of microorganisms occurring underneath meadows is limited in their ability to degrade simple sugars, which allows these compounds to persist in the environment over relatively long periods of time. Our findings reveal how seagrasses form blue carbon stocks despite the relatively small area they occupy. Unfortunately, anthropogenic disturbances are threatening the long-term persistence of seagrass meadows. Given that these sediments contain a large stock of sugars that heterotopic bacteria can degrade, it is even more important to protect these ecosystems from degradation.  | 
                                    
                                        
                                             | 
                                
| 205.9973 | [M-H2O+NH4]+PPM:2.4 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        20190614_MS1_A19r-20 - MTBLS1746Resolution: 17μm, 262x276
                                             Seagrasses are one of the most efficient natural sinks of carbon dioxide (CO2) on Earth. Despite covering less than 0.1% of coastal regions, they have the capacity to bury up to 10% of marine organic matter and can bury the same amount of carbon 35 times faster than tropical rainforests. On land, the soil’s ability to sequestrate carbon is intimately linked to microbial metabolism. Despite the growing attention to the link between plant production, microbial communities, and the carbon cycle in terrestrial ecosystems, these processes remain enigmatic in the sea. Here, we show that seagrasses excrete organic sugars, namely in the form of sucrose, into their rhizospheres. Surprisingly, the microbial communities living underneath meadows do not fully use this sugar stock in their metabolism. Instead, sucrose piles up in the sediments to mM concentrations underneath multiple types of seagrass meadows. Sediment incubation experiments show that microbial communities living underneath a meadow use sucrose at low metabolic rates. Our metagenomic analyses revealed that the distinct community of microorganisms occurring underneath meadows is limited in their ability to degrade simple sugars, which allows these compounds to persist in the environment over relatively long periods of time. Our findings reveal how seagrasses form blue carbon stocks despite the relatively small area they occupy. Unfortunately, anthropogenic disturbances are threatening the long-term persistence of seagrass meadows. Given that these sediments contain a large stock of sugars that heterotopic bacteria can degrade, it is even more important to protect these ecosystems from degradation.  | 
                                    
                                        
                                             | 
                                
| 206.9817 | [M+H]+PPM:0.5 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        20190614_MS1_A19r-20 - MTBLS1746Resolution: 17μm, 262x276
                                             Seagrasses are one of the most efficient natural sinks of carbon dioxide (CO2) on Earth. Despite covering less than 0.1% of coastal regions, they have the capacity to bury up to 10% of marine organic matter and can bury the same amount of carbon 35 times faster than tropical rainforests. On land, the soil’s ability to sequestrate carbon is intimately linked to microbial metabolism. Despite the growing attention to the link between plant production, microbial communities, and the carbon cycle in terrestrial ecosystems, these processes remain enigmatic in the sea. Here, we show that seagrasses excrete organic sugars, namely in the form of sucrose, into their rhizospheres. Surprisingly, the microbial communities living underneath meadows do not fully use this sugar stock in their metabolism. Instead, sucrose piles up in the sediments to mM concentrations underneath multiple types of seagrass meadows. Sediment incubation experiments show that microbial communities living underneath a meadow use sucrose at low metabolic rates. Our metagenomic analyses revealed that the distinct community of microorganisms occurring underneath meadows is limited in their ability to degrade simple sugars, which allows these compounds to persist in the environment over relatively long periods of time. Our findings reveal how seagrasses form blue carbon stocks despite the relatively small area they occupy. Unfortunately, anthropogenic disturbances are threatening the long-term persistence of seagrass meadows. Given that these sediments contain a large stock of sugars that heterotopic bacteria can degrade, it is even more important to protect these ecosystems from degradation.  | 
                                    
                                        
                                             | 
                                
| 228.9659 | [M+Na]+PPM:9.4 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        20190614_MS1_A19r-20 - MTBLS1746Resolution: 17μm, 262x276
                                             Seagrasses are one of the most efficient natural sinks of carbon dioxide (CO2) on Earth. Despite covering less than 0.1% of coastal regions, they have the capacity to bury up to 10% of marine organic matter and can bury the same amount of carbon 35 times faster than tropical rainforests. On land, the soil’s ability to sequestrate carbon is intimately linked to microbial metabolism. Despite the growing attention to the link between plant production, microbial communities, and the carbon cycle in terrestrial ecosystems, these processes remain enigmatic in the sea. Here, we show that seagrasses excrete organic sugars, namely in the form of sucrose, into their rhizospheres. Surprisingly, the microbial communities living underneath meadows do not fully use this sugar stock in their metabolism. Instead, sucrose piles up in the sediments to mM concentrations underneath multiple types of seagrass meadows. Sediment incubation experiments show that microbial communities living underneath a meadow use sucrose at low metabolic rates. Our metagenomic analyses revealed that the distinct community of microorganisms occurring underneath meadows is limited in their ability to degrade simple sugars, which allows these compounds to persist in the environment over relatively long periods of time. Our findings reveal how seagrasses form blue carbon stocks despite the relatively small area they occupy. Unfortunately, anthropogenic disturbances are threatening the long-term persistence of seagrass meadows. Given that these sediments contain a large stock of sugars that heterotopic bacteria can degrade, it is even more important to protect these ecosystems from degradation.  | 
                                    
                                        
                                             | 
                                
| 205.9972 | [M-H2O+NH4]+PPM:2.9 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        20190822_MS1_A19r-19 - MTBLS1746Resolution: 17μm, 303x309
                                             Seagrasses are among the most efficient sinks of carbon dioxide on Earth. While carbon sequestration in terrestrial plants is linked to the microorganisms living in their soils, the interactions of seagrasses with their rhizospheres are poorly understood. Here, we show that the seagrass, Posidonia oceanica excretes sugars, mainly sucrose, into its rhizosphere. These sugars accumulate to µM concentrations—nearly 80 times higher than previously observed in marine environments. This finding is unexpected as sugars are readily consumed by microorganisms. Our experiments indicated that under low oxygen conditions, phenolic compounds from P. oceanica inhibited microbial consumption of sucrose. Analyses of the rhizosphere community revealed that many microbes had the genes for degrading sucrose but these were only expressed by a few taxa that also expressed genes for degrading phenolics. Given that we observed high sucrose concentrations underneath three other species of marine plants, we predict that the presence of plant-produced phenolics under low oxygen conditions allows the accumulation of labile molecules across aquatic rhizospheres.  | 
                                    
                                        
                                             | 
                                
| 170.961 | [M+H-2H2O]+PPM:1.9 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        20190613_MS1_A19r-18 - MTBLS1746Resolution: 17μm, 246x264
                                              | 
                                    
                                        
                                             | 
                                
| 205.9977 | [M-H2O+NH4]+PPM:0.4 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        20190613_MS1_A19r-18 - MTBLS1746Resolution: 17μm, 246x264
                                              | 
                                    
                                        
                                             | 
                                
| 206.9821 | [M+H]+PPM:1.4 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        20190613_MS1_A19r-18 - MTBLS1746Resolution: 17μm, 246x264
                                              | 
                                    
                                        
                                             | 
                                
| 228.9664 | [M+Na]+PPM:11.6 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        20190613_MS1_A19r-18 - MTBLS1746Resolution: 17μm, 246x264
                                              | 
                                    
                                        
                                             | 
                                
| 206.9817 | [M+H]+PPM:0.5 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        20190828_MS1_A19r-22 - MTBLS1746Resolution: 17μm, 292x279
                                              | 
                                    
                                        
                                             | 
                                
| 170.9608 | [M+H-2H2O]+PPM:0.7 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        MS1_20180404_PO_1200 - MTBLS1746Resolution: 17μm, 193x208
                                              | 
                                    
                                        
                                             | 
                                
| 205.9973 | [M-H2O+NH4]+PPM:2.4 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        MS1_20180404_PO_1200 - MTBLS1746Resolution: 17μm, 193x208
                                              | 
                                    
                                        
                                             | 
                                
| 206.9817 | [M+H]+PPM:0.5 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        MS1_20180404_PO_1200 - MTBLS1746Resolution: 17μm, 193x208
                                              | 
                                    
                                        
                                             | 
                                
| 228.9663 | [M+Na]+PPM:11.1 | 
                                    Posidonia oceanica | root | MALDI (CHCA) | 
                                        MS1_20180404_PO_1200 - MTBLS1746Resolution: 17μm, 193x208
                                              | 
                                    
                                        
                                             | 
                                
| 170.9588 | [M+H-2H2O]+PPM:11 | 
                                    Homo sapiens | esophagus | DESI () | 
                                        LNTO22_1_9 - MTBLS385Resolution: 75μm, 89x74
                                              | 
                                    
                                        
                                             | 
                                
| 170.959 | [M+H-2H2O]+PPM:9.8 | 
                                    Homo sapiens | esophagus | DESI () | 
                                        LNTO22_1_7 - MTBLS385Resolution: 75μm, 69x54
                                              | 
                                    
                                        
                                             | 
                                
| 228.9643 | [M+Na]+PPM:2.4 | 
                                    Homo sapiens | esophagus | DESI () | 
                                        LNTO30_7_2 - MTBLS385Resolution: 75μm, 82x68
                                              | 
                                    
                                        
                                             | 
                                
| 205.9984 | [M-H2O+NH4]+PPM:3 | 
                                    Mus musculus | brain | MALDI (DHB) | 
                                        Brain01_Bregma1-42_01_centroid - MTBLS313Resolution: 17μm, 447x118
                                              | 
                                    
                                        
                                             | 
                                
| 205.9973 | [M-H2O+NH4]+PPM:2.4 | 
                                    Mus musculus | brain | MALDI (DHB) | 
                                        Brain02_Bregma1-42_03 - MTBLS313Resolution: 17μm, 483x403
                                              | 
                                    
                                        
                                             | 
                                
| 205.9973 | [M-H2O+NH4]+PPM:2.4 | 
                                    Mus musculus | brain | MALDI (DHB) | 
                                        Brain02_Bregma-3-88 - MTBLS313Resolution: 17μm, 288x282
                                              | 
                                    
                                        
                                             | 
                                
| 205.9973 | [M-H2O+NH4]+PPM:2.4 | 
                                    Mus musculus | brain | MALDI (DHB) | 
                                        Brain02_Bregma-1-46 - MTBLS313Resolution: 17μm, 294x399
                                              | 
                                    
                                        
                                             | 
                                
| 206.0013 | [M-H2O+NH4]+PPM:17 | 
                                    Homo sapiens | colorectal adenocarcinoma | DESI () | 
                                        240TopL, 210TopR, 230BottomL, 220BottomR-centroid - MTBLS176Resolution: 50μm, 142x141
                                              | 
                                    
                                        
                                             | 
                                
Etidronic acid is only found in individuals that have used or taken this drug. It is a diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover. [PubChem]Bisphosphonates, when attached to bone tissue, are absorbed by osteoclasts, the bone cells that breaks down bone tissue. Although the mechanism of action of non-nitrogenous bisphosphonates has not been fully elucidated, available data suggest that they bind strongly to hydroxyapatite crystals in the bone matrix, preferentially at the sites of increased bone turnover and inhibit the formation and dissolution of the crystals. Other actions may include direct inhibition of mature osteoclast function, promotion of osteoclast apoptosis, and interference with osteoblast-mediated osteoclast activation. Etidronic acid does not interfere with bone mineralization. In malignancy-related hypercalcemia, etidronic acid decreases serum calcium by inhibiting tumour-induced bone resorption and reducing calcium flow from the resorbing bone into the blood. Etidronic acid also reduces morbidity of osteolytic bone metastases by inhibiting tumour-induced bone resorption. Etidronic acid may promote osteoclast apoptosis by competing with adenosine triphosphate (ATP) in the cellular energy metabolism. The osteoclast initiates apoptosis and dies, leading to an overall decrease in the breakdown of bone. Food contaminant arising from its use as a boiler water additive for prepn. of steam used in food processing. Component of antimicrobial washes for poultry carcasses and fruit M - Musculo-skeletal system > M05 - Drugs for treatment of bone diseases > M05B - Drugs affecting bone structure and mineralization > M05BA - Bisphosphonates C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates KEIO_ID E010
