Pactimibe

2-{7-[(1-hydroxy-2,2-dimethylpropylidene)amino]-4,6-dimethyl-1-octyl-2,3-dihydro-1H-indol-5-yl}acetate

Formula: C25H40N2O3 (416.3039)
Chinese Name: 帕替麦布
BioDeep ID: BioDeep_00000182044 ( View LC/MS Profile)
SMILES: CCCCCCCCN1CCC2=C(C(=C(C(=C21)NC(=O)C(C)(C)C)C)CC(=O)O)C



Found 2 Sample Hits

m/z Adducts Species Organ Scanning Sample
434.3363 [M+NH4]+
PPM:3.2		 Homo sapiens esophagus DESI ()
LNTO22_1_3 - MTBLS385
Resolution: 75μm, 121x68

Description

434.3363 [M+NH4]+
PPM:3.2		 Homo sapiens esophagus DESI ()
LNTO26_16_1 - MTBLS385
Resolution: 75μm, 95x88

Description


D006133 - Growth Substances > D010937 - Plant Growth Regulators > D007210 - Indoleacetic Acids C471 - Enzyme Inhibitor Pactimibe (CS-505 free base) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe (CS-505 free base) inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively[1]. Pactimibe (CS-505 free base) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe (CS-505 free base) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe (CS-505 free base) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity[2].