PGP(a-13:0/a-25:0)

Found 18 Sample Hits

m/z	Adducts	Species	Organ	Scanning	Sample
887.5743	[M+H]+ PPM:3.3	Homo sapiens	esophagus	DESI ()	LNTO22_1_3 - MTBLS385 Resolution: 75μm, 121x68 Description
887.5728	[M+H]+ PPM:5	Homo sapiens	esophagus	DESI ()	LNTO29_16_2 - MTBLS385 Resolution: 17μm, 95x101 Description
887.5676	[M+H]+ PPM:10.9	Homo sapiens	esophagus	DESI ()	TO42T - MTBLS385 Resolution: 17μm, 69x81 Description
886.5936	[M-H2O+NH4]+ PPM:0.4	Homo sapiens	colorectal adenocarcinoma	DESI ()	520TopL, 490TopR, 510BottomL, 500BottomR-profile - MTBLS415 Resolution: 17μm, 147x131 Description The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024).
904.6126	[M+NH4]+ PPM:9.7	Homo sapiens	colorectal adenocarcinoma	DESI ()	520TopL, 490TopR, 510BottomL, 500BottomR-profile - MTBLS415 Resolution: 17μm, 147x131 Description The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024).
886.5927	[M-H2O+NH4]+ PPM:0.6	Homo sapiens	NA	DESI ()	160TopL,130TopR,150BottomL,140BottomR-profile - MTBLS415 Resolution: 17μm, 142x136 Description
887.5763	[M+H]+ PPM:1.1	Homo sapiens	esophagus	DESI ()	LNTO26_7_1 - MTBLS385 Resolution: 17μm, 75x74 Description
887.5757	[M+H]+ PPM:1.8	Homo sapiens	esophagus	DESI ()	LNTO26_7_2 - MTBLS385 Resolution: 17μm, 135x101 Description
887.5758	[M+H]+ PPM:1.6	Homo sapiens	esophagus	DESI ()	LNTO26_7_3 - MTBLS385 Resolution: 75μm, 82x88 Description
887.5724	[M+H]+ PPM:5.5	Homo sapiens	esophagus	DESI ()	LNTO30_8M_2 - MTBLS385 Resolution: 75μm, 108x68 Description
887.5728	[M+H]+ PPM:5	Homo sapiens	esophagus	DESI ()	LNTO30_8M_4 - MTBLS385 Resolution: 75μm, 62x48 Description
887.5728	[M+H]+ PPM:5	Homo sapiens	esophagus	DESI ()	LNTO30_8M_5 - MTBLS385 Resolution: 75μm, 56x54 Description
887.574	[M+H]+ PPM:3.7	Homo sapiens	esophagus	DESI ()	LNTO30_17_2 - MTBLS385 Resolution: 75μm, 82x54 Description
887.575	[M+H]+ PPM:2.5	Homo sapiens	esophagus	DESI ()	LNTO22_1_5 - MTBLS385 Resolution: 75μm, 135x94 Description
887.5739	[M+H]+ PPM:3.8	Homo sapiens	esophagus	DESI ()	LNTO22_1_8 - MTBLS385 Resolution: 75μm, 69x61 Description
887.5757	[M+H]+ PPM:1.8	Homo sapiens	esophagus	DESI ()	LNTO26_16_1 - MTBLS385 Resolution: 75μm, 95x88 Description
887.5739	[M+H]+ PPM:3.8	Homo sapiens	esophagus	DESI ()	LNTO30_7_1 - MTBLS385 Resolution: 75μm, 69x68 Description
887.5727	[M+H]+ PPM:5.1	Homo sapiens	esophagus	DESI ()	LNTO30_7_2 - MTBLS385 Resolution: 75μm, 82x68 Description

PGP(a-13:0/a-25:0) is a phosphatidylglycerophosphate (PGP). It is a glycerophospholipid in which a phosphoglycerol moiety occupies a glycerol substitution site followed by another phosphate moiety. Phosphatidylglycerolphosphate is present at a level of 1-2\\% in most animal tissues, but it can be the second most abundant phospholipid in lung surfactant (up to 11\\% of the total). It is well established that the concentration of phosphatidylglycerolphosphate increases during fetal development. Phosphatidylglycerolphosphate may be present in animal tissues merely as a precursor for cardiolipin synthesis. As is the case with diacylglycerols, phosphatidylglycerophosphates can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PGP(a-13:0/a-25:0), in particular, consists of one chain of anteisotridecanoic acid at the C-1 position and one chain of anteisopentacosanoic acid at the C-2 position. They are synthesized by the addition of glycerol 3-phosphate to a CDP-diacylglycerol. In turn, PGPs are dephosphorylated to phosphatidylglycerols (PGs). While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes.