M/Z: 765.513

Hit 2 annotations: Narasin_[M+H]+; PA(18:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4))_[M+H]+

在BioDeep NovoCell知识数据库中，参考离子总共被划分为4个级别。

Confirmed: 这个参考离子已经通过手动审计得到确认和验证。
Reliable: 这个参考离子可能在特定的解剖组织环境中高度保守。
Unreliable: 这个参考离子具有较高的排名价值，但缺乏可重复性。
Unavailable: 由于排名价值低且缺乏可重复性，这个参考离子不应用于注释。

Found 5 Reference Ions Near m/z 765.513

NovoCell ID	m/z	Mass Window	Metabolite	Ranking	Anatomy Context
MSI_000052217 Unreliable	765.513	765.513 ~ 765.513 MzDiff: `none`	Not Annotated	2.27 (%)	Homo sapiens [UBERON:0001052] rectum
MSI_000047221 Unreliable	765.517	765.517 ~ 765.517 MzDiff: `none`	PA(18:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4)) (BioDeep_00000188649) Formula: C43H73O9P (764.4992)	2.54 (100%)	Homo sapiens [UBERON:0013067] colorectal mucosa
MSI_000051776 Unreliable	765.5183	765.5183 ~ 765.5183 MzDiff: `none`	Clarithromycin (BioDeep_00000002154) Formula: C38H69NO13 (747.4769)	2.46 (100%)	Homo sapiens [UBERON:0001052] rectum
MSI_000049590 Unreliable	765.5105	765.5105 ~ 765.5105 MzDiff: `none`	Narasin (BioDeep_00000017926) Formula: C43H72O11 (764.5074)	1.83 (100%)	Mytilus edulis [UBERON:0009120] gill filament
MSI_000051003 Unreliable	765.5105	765.5105 ~ 765.5105 MzDiff: `none`	Narasin (BioDeep_00000017926) Formula: C43H72O11 (764.5074)	0.33 (100%)	Mytilus edulis [UBERON:2001856] gill ray

Found 7 Sample Hits

Metabolite	Species	Sample
Narasin Formula: C43H72O11 (764.5074) Adducts: [M+H]+ (Ppm: 7.7)	Mus musculus (Liver)	Salmonella_final_pos_recal Resolution: 17μm, 691x430 Description A more complete and holistic view on host–microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, we developed a multimodal imaging approach combining histopathology with mass spectrometry imaging (MSI) and same section imaging mass cytometry (IMC) to study the effects of Salmonella Typhimurium infection in the liver of a mouse model using the S. Typhimurium strains SL3261 and SL1344. This approach enables correlation of tissue morphology and specific cell phenotypes with molecular images of tissue metabolism. IMC revealed a marked increase in immune cell markers and localization in immune aggregates in infected tissues. A correlative computational method (network analysis) was deployed to find metabolic features associated with infection and revealed metabolic clusters of acetyl carnitines, as well as phosphatidylcholine and phosphatidylethanolamine plasmalogen species, which could be associated with pro-inflammatory immune cell types. By developing an IMC marker for the detection of Salmonella LPS, we were further able to identify and characterize those cell types which contained S. Typhimurium. [dataset] Nicole Strittmatter. Holistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging, metabolights_dataset, V1; 2022. https://www.ebi.ac.uk/metabolights/MTBLS2671.
m/z_765.5099 Formula: - (n/a) Adducts: (Ppm: )	Homo sapiens (colorectal adenocarcinoma)	80TopL, 50TopR, 70BottomL, 60BottomR-profile Resolution: 17μm, 137x136 Description The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024).
PA(18:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4)) Formula: C43H73O9P (764.4992) Adducts: [M+H]+ (Ppm: 13.8)	Homo sapiens (colorectal adenocarcinoma)	80TopL, 50TopR, 70BottomL, 60BottomR-profile Resolution: 17μm, 137x136 Description The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024).
Narasin Formula: C43H72O11 (764.5074) Adducts: [M+H]+ (Ppm: 5.5)	Mytilus edulis (gill)	20190202_MS38_Crassostrea_Gill_350-1500_DHB_pos_A25_11um_305x210 Resolution: 11μm, 305x210 Description single cell layer `class_4` is the gill structure cells, metabolite ion 534.2956 is the top representive ion of this type of cell
m/z_765.51 Formula: - (n/a) Adducts: (Ppm: )	Homo sapiens (colorectal adenocarcinoma)	520TopL, 490TopR, 510BottomL, 500BottomR-profile Resolution: 17μm, 147x131 Description The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024).
PA(18:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4)) Formula: C43H73O9P (764.4992) Adducts: [M+H]+ (Ppm: 13.9)	Homo sapiens (colorectal adenocarcinoma)	520TopL, 490TopR, 510BottomL, 500BottomR-profile Resolution: 17μm, 147x131 Description The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024).
m/z_765.513 Formula: - (n/a) Adducts: (Ppm: )	Homo sapiens (colorectal adenocarcinoma)	439TopL, 409TopR, 429BottomL, 419BottomR-profile Resolution: 17μm, 157x136 Description The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024).