M/Z: 598.9565
Hit 0 annotations:
- Confirmed: 这个参考离子已经通过手动审计得到确认和验证。
- Reliable: 这个参考离子可能在特定的解剖组织环境中高度保守。
- Unreliable: 这个参考离子具有较高的排名价值,但缺乏可重复性。
- Unavailable: 由于排名价值低且缺乏可重复性,这个参考离子不应用于注释。
Found 7 Reference Ions Near m/z 598.9565
NovoCell ID | m/z | Mass Window | Metabolite | Ranking | Anatomy Context |
---|---|---|---|---|---|
MSI_000046724 Reliable | 598.9592 | 598.9592 ~ 598.9592 MzDiff: none |
Not Annotated | 3.62 (%) | Mus musculus [UBERON:0002107] liver |
MSI_000011286 Unreliable | 598.9482 | 598.9482 ~ 598.9482 MzDiff: none |
Not Annotated | 1.44 (%) | Mus musculus [UBERON:0012378] muscle layer of urinary bladder |
MSI_000000216 Unreliable | 598.9482 | 598.9482 ~ 598.9482 MzDiff: none |
Not Annotated | 1.52 (%) | Mus musculus [CL:0000066] epithelial cell |
MSI_000013670 Unreliable | 598.9565 | 598.9565 ~ 598.9565 MzDiff: none |
Not Annotated | 0.43 (%) | Plant [PO:0005417] phloem |
MSI_000014610 Unreliable | 598.9565 | 598.9565 ~ 598.9565 MzDiff: none |
Not Annotated | 0.29 (%) | Plant [PO:0006036] root epidermis |
MSI_000019135 Unavailable | 598.9565 | 598.9565 ~ 598.9565 MzDiff: none |
Not Annotated | -0.96 (%) | Plant [PO:0020124] root stele |
MSI_000019221 Unreliable | 598.9565 | 598.9565 ~ 598.9565 MzDiff: none |
Not Annotated | 1.3 (%) | Plant [PO:0025197] stele |
Found 2 Sample Hits
Metabolite | Species | Sample | |
---|---|---|---|
m/z_598.9565 Formula: - (n/a) Adducts: (Ppm: ) |
Plant (Root) |
MPIMM_035_QE_P_PO_6pmResolution: 30μm, 165x170
|
|
m/z_598.9592 Formula: - (n/a) Adducts: (Ppm: ) |
Mus musculus (Liver) |
Salmonella_final_pos_recalResolution: 17μm, 691x430
A more complete and holistic view on host–microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, we developed a multimodal imaging approach combining histopathology with mass spectrometry imaging (MSI) and same section imaging mass cytometry (IMC) to study the effects of Salmonella Typhimurium infection in the liver of a mouse model using the S. Typhimurium strains SL3261 and SL1344. This approach enables correlation of tissue morphology and specific cell phenotypes with molecular images of tissue metabolism. IMC revealed a marked increase in immune cell markers and localization in immune aggregates in infected tissues. A correlative computational method (network analysis) was deployed to find metabolic features associated with infection and revealed metabolic clusters of acetyl carnitines, as well as phosphatidylcholine and phosphatidylethanolamine plasmalogen species, which could be associated with pro-inflammatory immune cell types. By developing an IMC marker for the detection of Salmonella LPS, we were further able to identify and characterize those cell types which contained S. Typhimurium.
[dataset] Nicole Strittmatter. Holistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging, metabolights_dataset, V1; 2022. https://www.ebi.ac.uk/metabolights/MTBLS2671. |
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