- Confirmed: 这个参考离子已经通过手动审计得到确认和验证。
- Reliable: 这个参考离子可能在特定的解剖组织环境中高度保守。
- Unreliable: 这个参考离子具有较高的排名价值,但缺乏可重复性。
- Unavailable: 由于排名价值低且缺乏可重复性,这个参考离子不应用于注释。
Found 10 Reference Ions Near m/z 533.3868
NovoCell ID | m/z | Mass Window | Metabolite | Ranking | Anatomy Context |
---|---|---|---|---|---|
MSI_000011537 Unavailable | 533.3799 | 533.3799 ~ 533.3799 MzDiff: none |
Alisol A 24-acetate (BioDeep_00000185415) Formula: C32H52O6 (532.3764) |
-0.47 (100%) | Mus musculus [UBERON:0012378] muscle layer of urinary bladder |
MSI_000011556 Unavailable | 533.3868 | 533.3868 ~ 533.3868 MzDiff: none |
Not Annotated | -0.82 (%) | Mus musculus [UBERON:0012378] muscle layer of urinary bladder |
MSI_000011578 Unavailable | 533.3944 | 533.3944 ~ 533.3944 MzDiff: none |
(3e,5e,7s,8s,10e,13s,14r,15e,19s)-8-{[(2r,4s,5s,6r)-4-hydroxy-6-methyl-5-(methylamino)oxan-2-yl]oxy}-7,11,13,14,19-pentamethyl-1-azacycloicosa-1,3,5,10,15-pentaene-2,13-diol (BioDeep_00002218477) Formula: C31H52N2O5 (532.3876) |
-1.06 (100%) | Mus musculus [UBERON:0012378] muscle layer of urinary bladder |
MSI_000009579 Unavailable | 533.3868 | 533.3868 ~ 533.3868 MzDiff: none |
Not Annotated | -0.97 (%) | Mus musculus [UBERON:0004645] urinary bladder urothelium |
MSI_000009642 Unavailable | 533.3944 | 533.3944 ~ 533.3944 MzDiff: none |
(3e,5e,7s,8s,10e,13s,14r,15e,19s)-8-{[(2r,4s,5s,6r)-4-hydroxy-6-methyl-5-(methylamino)oxan-2-yl]oxy}-7,11,13,14,19-pentamethyl-1-azacycloicosa-1,3,5,10,15-pentaene-2,13-diol (BioDeep_00002218477) Formula: C31H52N2O5 (532.3876) |
-1.21 (100%) | Mus musculus [UBERON:0004645] urinary bladder urothelium |
MSI_000050336 Unreliable | 533.3792 | 533.3792 ~ 533.3792 MzDiff: none |
Alisol A 24-acetate (BioDeep_00000185415) Formula: C32H52O6 (532.3764) |
(100%) | Mytilus edulis [UBERON:0009120] gill filament |
MSI_000000307 Unreliable | 533.3799 | 533.3799 ~ 533.3799 MzDiff: none |
Alisol A 24-acetate (BioDeep_00000185415) Formula: C32H52O6 (532.3764) |
0.9 (100%) | Mus musculus [CL:0000066] epithelial cell |
MSI_000004160 Unreliable | 533.3808 | 533.3808 ~ 533.3808 MzDiff: none |
Alisol A 24-acetate (BioDeep_00000185415) Formula: C32H52O6 (532.3764) |
0.96 (100%) | Homo sapiens [UBERON:0002107] liver |
MSI_000000350 Unreliable | 533.3868 | 533.3868 ~ 533.3868 MzDiff: none |
Not Annotated | 0.57 (%) | Mus musculus [CL:0000066] epithelial cell |
MSI_000000335 Unreliable | 533.3944 | 533.3944 ~ 533.3944 MzDiff: none |
(3e,5e,7s,8s,10e,13s,14r,15e,19s)-8-{[(2r,4s,5s,6r)-4-hydroxy-6-methyl-5-(methylamino)oxan-2-yl]oxy}-7,11,13,14,19-pentamethyl-1-azacycloicosa-1,3,5,10,15-pentaene-2,13-diol (BioDeep_00002218477) Formula: C31H52N2O5 (532.3876) |
0.7 (100%) | Mus musculus [CL:0000066] epithelial cell |
Found 3 Sample Hits
Metabolite | Species | Sample | |
---|---|---|---|
m/z_533.3868 Formula: - (n/a) Adducts: (Ppm: ) |
Mus musculus (Urinary bladder) |
HR2MSI_mouse_urinary_bladder - S096Resolution: 10μm, 260x134
Mass spectrometry imaging of phospholipids in mouse urinary bladder (imzML dataset) |
|
Alisol A 24-acetate Formula: C32H52O6 (532.3764) Adducts: [M+H]+ (Ppm: 5.5) |
Mus musculus (Liver) |
Salmonella_final_pos_recalResolution: 17μm, 691x430
A more complete and holistic view on host–microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, we developed a multimodal imaging approach combining histopathology with mass spectrometry imaging (MSI) and same section imaging mass cytometry (IMC) to study the effects of Salmonella Typhimurium infection in the liver of a mouse model using the S. Typhimurium strains SL3261 and SL1344. This approach enables correlation of tissue morphology and specific cell phenotypes with molecular images of tissue metabolism. IMC revealed a marked increase in immune cell markers and localization in immune aggregates in infected tissues. A correlative computational method (network analysis) was deployed to find metabolic features associated with infection and revealed metabolic clusters of acetyl carnitines, as well as phosphatidylcholine and phosphatidylethanolamine plasmalogen species, which could be associated with pro-inflammatory immune cell types. By developing an IMC marker for the detection of Salmonella LPS, we were further able to identify and characterize those cell types which contained S. Typhimurium.
[dataset] Nicole Strittmatter. Holistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging, metabolights_dataset, V1; 2022. https://www.ebi.ac.uk/metabolights/MTBLS2671. |
|
Alisol A 24-acetate Formula: C32H52O6 (532.3764) Adducts: [M+H]+ (Ppm: 8.3) |
Mytilus edulis (gill) |
20190202_MS38_Crassostrea_Gill_350-1500_DHB_pos_A25_11um_305x210Resolution: 11μm, 305x210
single cell layer |
|