- Confirmed: 这个参考离子已经通过手动审计得到确认和验证。
- Reliable: 这个参考离子可能在特定的解剖组织环境中高度保守。
- Unreliable: 这个参考离子具有较高的排名价值，但缺乏可重复性。
- Unavailable: 由于排名价值低且缺乏可重复性，这个参考离子不应用于注释。
Found 5 Reference Ions Near m/z 392.2865
| NovoCell ID | m/z | Mass Window | Metabolite | Ranking | Anatomy Context |
|---|---|---|---|---|---|
| MSI_000017385 Reliable | 392.2876 | 392.2876 ~ 392.2876 MzDiff: 0.0 ppm |
Deoxycholate (BioDeep_00000000113) Formula: C24H40O4 (392.2926) |
2.57 (100%) | Vitis vinifera [PO:0009087] mesocarp |
| MSI_000046087 Reliable | 392.2767 | 392.2767 ~ 392.2767 MzDiff: none |
N-Stearoyltaurine (BioDeep_00000169933) Formula: C20H41NO4S (391.2756) |
6.49 (100%) | Mus musculus [UBERON:0002107] liver |
| MSI_000016516 Unreliable | 392.2876 | 392.2876 ~ 392.2876 MzDiff: 0.0 ppm |
Deoxycholate (BioDeep_00000000113) Formula: C24H40O4 (392.2926) |
0.72 (100%) | Vitis vinifera [PO:0009086] endocarp |
| MSI_000051178 Unreliable | 392.2793 | 392.2793 ~ 392.2793 MzDiff: none |
N-Stearoyltaurine (BioDeep_00000169933) Formula: C20H41NO4S (391.2756) |
(100%) | Mytilus edulis [UBERON:2001856] gill ray |
| MSI_000030182 Unreliable | 392.2865 | 392.2865 ~ 392.2865 MzDiff: none |
N-Stearoyltaurine (BioDeep_00000169933) Formula: C20H41NO4S (391.2756) |
2.15 (100%) | Macropus giganteus [UBERON:0003027] cingulate cortex |
Found 5 Sample Hits
| Metabolite | Species | Sample | |
|---|---|---|---|
| Deoxycholate Formula: C24H40O4 (392.2926) Adducts: [M]+ (Ppm: 11.5) |
Vitis vinifera (Fruit) |
grape_dhb_91_1Resolution: 50μm, 120x114
Grape berries fruit, condition: Ripe |
|
| Deoxycholate Formula: C24H40O4 (392.2926) Adducts: [M]+ (Ppm: 11.5) |
Vitis vinifera (Fruit) |
grape_dhb_164_1Resolution: 17μm, 136x122
Grape berries fruit, condition: Late |
|
| Deoxycholate Formula: C24H40O4 (392.2926) Adducts: [M]+ (Ppm: 11.5) |
Vitis vinifera (Fruit) |
grape_dhb_163_1Resolution: 17μm, 132x115
Grape berries fruit, condition: Late |
|
| N-Stearoyltaurine Formula: C20H41NO4S (391.2756) Adducts: [M+H]+ (Ppm: 9.2) |
Macropus giganteus (Brain) |
170321_kangaroobrain-dan3-pos_maxof50.0_med1Resolution: 50μm, 81x50
Sample information
Organism: Macropus giganteus (kangaroo)
Organism part: Brain
Condition: Wildtype
Sample growth conditions: Wild |
|
| N-Stearoyltaurine Formula: C20H41NO4S (391.2756) Adducts: [M+H]+ (Ppm: 15.8) |
Mus musculus (Liver) |
Salmonella_final_pos_recalResolution: 17μm, 691x430
A more complete and holistic view on host–microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, we developed a multimodal imaging approach combining histopathology with mass spectrometry imaging (MSI) and same section imaging mass cytometry (IMC) to study the effects of Salmonella Typhimurium infection in the liver of a mouse model using the S. Typhimurium strains SL3261 and SL1344. This approach enables correlation of tissue morphology and specific cell phenotypes with molecular images of tissue metabolism. IMC revealed a marked increase in immune cell markers and localization in immune aggregates in infected tissues. A correlative computational method (network analysis) was deployed to find metabolic features associated with infection and revealed metabolic clusters of acetyl carnitines, as well as phosphatidylcholine and phosphatidylethanolamine plasmalogen species, which could be associated with pro-inflammatory immune cell types. By developing an IMC marker for the detection of Salmonella LPS, we were further able to identify and characterize those cell types which contained S. Typhimurium.
[dataset] Nicole Strittmatter. Holistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging, metabolights_dataset, V1; 2022. https://www.ebi.ac.uk/metabolights/MTBLS2671. |
|
