M/Z: 381.11
Hit 4 annotations: Picraquassioside A_[M+H-H2O]+; Meticillin_[M+H]+; Celecoxib_[M-H2O+NH4]+; S-adenosyl-4-methylthio-2-oxobutanoate_[M+H-H2O]+
- Confirmed: 这个参考离子已经通过手动审计得到确认和验证。
- Reliable: 这个参考离子可能在特定的解剖组织环境中高度保守。
- Unreliable: 这个参考离子具有较高的排名价值，但缺乏可重复性。
- Unavailable: 由于排名价值低且缺乏可重复性，这个参考离子不应用于注释。
Found 4 Reference Ions Near m/z 381.11
| NovoCell ID | m/z | Mass Window | Metabolite | Ranking | Anatomy Context |
|---|---|---|---|---|---|
| MSI_000018098 Reliable | 381.1004 | 381.1004 ~ 381.1005 MzDiff: 0.3 ppm |
Daidzin (BioDeep_00000002593) Formula: C21H20O9 (416.1107) |
0.48 (100%) | Vitis vinifera [PO:0009087] mesocarp |
| MSI_000054958 Unreliable | 381.1124 | 381.1122 ~ 381.1126 MzDiff: 1.8 ppm |
Meticillin (BioDeep_00000006437) Formula: C17H20N2O6S (380.1042) |
1.6 (100%) | MALDI - DHB [NOVOCELL:BACKGROUND] blank |
| MSI_000016562 Unreliable | 381.1004 | 381.1004 ~ 381.1004 MzDiff: 0.0 ppm |
Daidzin (BioDeep_00000002593) Formula: C21H20O9 (416.1107) |
0.57 (100%) | Vitis vinifera [PO:0009086] endocarp |
| MSI_000065982 Unreliable | 381.11 | 381.11 ~ 381.11 MzDiff: none |
Meticillin (BioDeep_00000006437) Formula: C17H20N2O6S (380.1042) |
0.83 (100%) | Homo sapiens [UBERON:0007779] transudate |
Found 10 Sample Hits
| Metabolite | Species | Sample | |
|---|---|---|---|
| Picraquassioside A Formula: C18H22O10 (398.1213) Adducts: [M+H-H2O]+ (Ppm: 15) |
Posidonia oceanica (root) |
20190613_MS1_A19r-18Resolution: 17μm, 246x264
|
|
| Meticillin Formula: C17H20N2O6S (380.1042) Adducts: [M+H]+ (Ppm: 4.4) |
Mus musculus (Liver) |
Salmonella_final_pos_recalResolution: 17μm, 691x430
A more complete and holistic view on host–microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, we developed a multimodal imaging approach combining histopathology with mass spectrometry imaging (MSI) and same section imaging mass cytometry (IMC) to study the effects of Salmonella Typhimurium infection in the liver of a mouse model using the S. Typhimurium strains SL3261 and SL1344. This approach enables correlation of tissue morphology and specific cell phenotypes with molecular images of tissue metabolism. IMC revealed a marked increase in immune cell markers and localization in immune aggregates in infected tissues. A correlative computational method (network analysis) was deployed to find metabolic features associated with infection and revealed metabolic clusters of acetyl carnitines, as well as phosphatidylcholine and phosphatidylethanolamine plasmalogen species, which could be associated with pro-inflammatory immune cell types. By developing an IMC marker for the detection of Salmonella LPS, we were further able to identify and characterize those cell types which contained S. Typhimurium.
[dataset] Nicole Strittmatter. Holistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging, metabolights_dataset, V1; 2022. https://www.ebi.ac.uk/metabolights/MTBLS2671. |
|
| Celecoxib Formula: C17H14F3N3O2S (381.0759) Adducts: [M-H2O+NH4]+ (Ppm: 17.2) |
Homo sapiens (colorectal adenocarcinoma) |
80TopL, 50TopR, 70BottomL, 60BottomR-profileResolution: 17μm, 137x136
The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024). |
|
| Meticillin Formula: C17H20N2O6S (380.1042) Adducts: [M+H]+ (Ppm: 8.2) |
Homo sapiens (colorectal adenocarcinoma) |
80TopL, 50TopR, 70BottomL, 60BottomR-profileResolution: 17μm, 137x136
The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024). |
|
| Meticillin Formula: C17H20N2O6S (380.1042) Adducts: [M+H]+ (Ppm: 2.9) |
Mytilus edulis (mantle) |
20190201_MS38_Crassostrea_Mantle_350-1500_DHB_pos_A28_10um_270x210Resolution: 10μm, 270x210
|
|
| Meticillin Formula: C17H20N2O6S (380.1042) Adducts: [M+H]+ (Ppm: 1.9) |
Mytilus edulis (gill) |
20190202_MS38_Crassostrea_Gill_350-1500_DHB_pos_A25_11um_305x210Resolution: 11μm, 305x210
single cell layer |
|
| Meticillin Formula: C17H20N2O6S (380.1042) Adducts: [M+H]+ (Ppm: 1.9) |
Mytilus edulis (mantle) |
20190216_MS38_Mytilus_mantle_350-1500_DHB_pos_A26_10um_275x210Resolution: 10μm, 275x210
|
|
| S-adenosyl-4-methylthio-2-oxobutanoate Formula: C15H20N5O6S+ (398.1134) Adducts: [M+H-H2O]+ (Ppm: 10.3) |
Homo sapiens (esophagus) |
LNTO22_1_8Resolution: 75μm, 69x61
|
|
| Meticillin Formula: C17H20N2O6S (380.1042) Adducts: [M+H]+ (Ppm: 3.9) |
Homo sapiens (colorectal adenocarcinoma) |
240TopL, 210TopR, 230BottomL, 220BottomR-centroidResolution: 50μm, 142x141
|
|
| Meticillin Formula: C17H20N2O6S (380.1042) Adducts: [M+H]+ (Ppm: 2.8) |
Homo sapiens (colorectal adenocarcinoma) |
120TopL, 90TopR, 110BottomL, 100BottomR-centroidResolution: 50μm, 132x136
|
|
