M/Z: 193.9894
Hit 4 annotations: dimethoate_[M+H-2H2O]+; 1,2-dihydro-1λ³-iodinine_[M-H2O+NH4]+; Dimethoate_[M+H-2H2O]+; 4-Chloro-6,7-dimethoxy-2-benzoxazolinone_[M+H-2H2O]+
- Confirmed: 这个参考离子已经通过手动审计得到确认和验证。
- Reliable: 这个参考离子可能在特定的解剖组织环境中高度保守。
- Unreliable: 这个参考离子具有较高的排名价值，但缺乏可重复性。
- Unavailable: 由于排名价值低且缺乏可重复性，这个参考离子不应用于注释。
Found 7 Reference Ions Near m/z 193.9894
| NovoCell ID | m/z | Mass Window | Metabolite | Ranking | Anatomy Context |
|---|---|---|---|---|---|
| MSI_000040619 Unreliable | 193.9802 | 193.9802 ~ 193.9803 MzDiff: 0.1 ppm |
1,2-dihydro-1λ³-iodinine (BioDeep_00002275001) Formula: C5H7I (193.9592) |
3.45 (100%) | Posidonia oceanica [PO:0006036] root epidermis |
| MSI_000033615 Unreliable | 193.9799 | 193.9799 ~ 193.9799 MzDiff: none |
1,2-dihydro-1λ³-iodinine (BioDeep_00002275001) Formula: C5H7I (193.9592) |
1.39 (100%) | Posidonia oceanica [PO:0005352] xylem |
| MSI_000035127 Unreliable | 193.9799 | 193.9799 ~ 193.9799 MzDiff: none |
1,2-dihydro-1λ³-iodinine (BioDeep_00002275001) Formula: C5H7I (193.9592) |
1.7 (100%) | Posidonia oceanica [PO:0006203] pericycle |
| MSI_000012991 Unavailable | 193.9808 | 193.9808 ~ 193.9808 MzDiff: none |
Picric acid (BioDeep_00000182423) Formula: C6H3N3O7 (228.9971) |
-0.59 (100%) | Plant [PO:0005020] vascular bundle |
| MSI_000014564 Unreliable | 193.9808 | 193.9808 ~ 193.9808 MzDiff: none |
Picric acid (BioDeep_00000182423) Formula: C6H3N3O7 (228.9971) |
0.56 (100%) | Plant [PO:0006036] root epidermis |
| MSI_000018761 Unreliable | 193.9808 | 193.9808 ~ 193.9808 MzDiff: none |
Picric acid (BioDeep_00000182423) Formula: C6H3N3O7 (228.9971) |
1.49 (100%) | Plant [PO:0020124] root stele |
| MSI_000020126 Unavailable | 193.9808 | 193.9808 ~ 193.9808 MzDiff: none |
Picric acid (BioDeep_00000182423) Formula: C6H3N3O7 (228.9971) |
-0.53 (100%) | Plant [PO:0025197] stele |
Found 5 Sample Hits
| Metabolite | Species | Sample | |
|---|---|---|---|
| dimethoate Formula: C5H12NO3PS2 (228.9996) Adducts: [M+H-2H2O]+ (Ppm: 17.7) |
Vitis vinifera (Fruit) |
grape_dhb_164_1Resolution: 17μm, 136x122
Grape berries fruit, condition: Late |
|
| dimethoate Formula: C5H12NO3PS2 (228.9996) Adducts: [M+H-2H2O]+ (Ppm: 18.7) |
Vitis vinifera (Fruit) |
grape_dhb_163_1Resolution: 17μm, 132x115
Grape berries fruit, condition: Late |
|
| 1,2-dihydro-1λ³-iodinine Formula: C5H7I (193.9592) Adducts: [M-H2O+NH4]+ (Ppm: 11.4) |
Posidonia oceanica (root) |
MS1_20180404_PO_1200Resolution: 17μm, 193x208
|
|
| Dimethoate Formula: C5H12NO3PS2 (228.9996) Adducts: [M+H-2H2O]+ (Ppm: 12.7) |
Mus musculus (Liver) |
Salmonella_final_pos_recalResolution: 17μm, 691x430
A more complete and holistic view on host–microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, we developed a multimodal imaging approach combining histopathology with mass spectrometry imaging (MSI) and same section imaging mass cytometry (IMC) to study the effects of Salmonella Typhimurium infection in the liver of a mouse model using the S. Typhimurium strains SL3261 and SL1344. This approach enables correlation of tissue morphology and specific cell phenotypes with molecular images of tissue metabolism. IMC revealed a marked increase in immune cell markers and localization in immune aggregates in infected tissues. A correlative computational method (network analysis) was deployed to find metabolic features associated with infection and revealed metabolic clusters of acetyl carnitines, as well as phosphatidylcholine and phosphatidylethanolamine plasmalogen species, which could be associated with pro-inflammatory immune cell types. By developing an IMC marker for the detection of Salmonella LPS, we were further able to identify and characterize those cell types which contained S. Typhimurium.
[dataset] Nicole Strittmatter. Holistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging, metabolights_dataset, V1; 2022. https://www.ebi.ac.uk/metabolights/MTBLS2671. |
|
| 4-Chloro-6,7-dimethoxy-2-benzoxazolinone Formula: C9H8ClNO4 (229.0142) Adducts: [M+H-2H2O]+ (Ppm: 9.4) |
Mus musculus (Liver) |
Salmonella_final_pos_recalResolution: 17μm, 691x430
A more complete and holistic view on host–microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, we developed a multimodal imaging approach combining histopathology with mass spectrometry imaging (MSI) and same section imaging mass cytometry (IMC) to study the effects of Salmonella Typhimurium infection in the liver of a mouse model using the S. Typhimurium strains SL3261 and SL1344. This approach enables correlation of tissue morphology and specific cell phenotypes with molecular images of tissue metabolism. IMC revealed a marked increase in immune cell markers and localization in immune aggregates in infected tissues. A correlative computational method (network analysis) was deployed to find metabolic features associated with infection and revealed metabolic clusters of acetyl carnitines, as well as phosphatidylcholine and phosphatidylethanolamine plasmalogen species, which could be associated with pro-inflammatory immune cell types. By developing an IMC marker for the detection of Salmonella LPS, we were further able to identify and characterize those cell types which contained S. Typhimurium.
[dataset] Nicole Strittmatter. Holistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging, metabolights_dataset, V1; 2022. https://www.ebi.ac.uk/metabolights/MTBLS2671. |
|
