MSI_000056562

Reliable

排名分数: 3.52
参考来源: DESI (NOVOCELL:BACKGROUND: blank)

M/z: 418.3408
Mass Window: 418.3408 ~ 418.3409 (0.4 ppm)

参考注释

ST 27:1;O3_[M]+ (BioDeep_00000636711)
(20R,22R)-20,22-Dihydroxycholesterol;(22R)-20alpha,22-Dihydroxycholesterol

Formula: C27H46O3 (418.34467659999996)
SMILES: [C@@]12([C@]([C@H](O)C=C3[C@@]1(CC[C@@H](C3)O)C)([H])[C@]1([H])CC[C@]([H])([C@@H](CC[C@H](O)C(C)C)C)[C@@]1(C)CC2)[H]

7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2].