MSI_000043123

Unreliable

排名分数: 2.79
参考来源: Homo sapiens (UBERON:0001043: esophagus)

M/z: 287.1656
Mass Window: 287.1656 ~ 287.1657 (0.3 ppm)

参考注释

ST 18:4;O3_[M+H]+ (BioDeep_00000637483)
3,16alpha-dihydroxy-1,3,5(10)-estratrien-17-one

Formula: C18H22O3 (286.15688620000003)
SMILES: [C@@]12([H])CCC3C=C(O)C=CC=3[C@@]1([H])CC[C@]1(C)[C@@H](O)C(=O)C[C@@]21[H]

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen D020011 - Protective Agents > D016588 - Anticarcinogenic Agents D000970 - Antineoplastic Agents 4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity[1].