2,3-Dihydroxy-5-methylthio-4-pentenoic acid

(2R,3R,4E)-2,3-Dihydroxy-5-(methylsulphanyl)pent-4-enoic acid

Formula: C6H10O4S (178.03)
Chinese Name: 2,3-二羟基-5-甲硫基-4-戊烯酸
BioDeep ID: BioDeep_00000169780 ( View LC/MS Profile)
SMILES: CS\C=C\[C@@H](O)[C@@H](O)C(O)=O



Found 19 Sample Hits

m/z Adducts Species Organ Scanning Sample
161.024 [M+H-H2O]+
PPM:16.7		 Homo sapiens esophagus DESI ()
LNTO22_1_3 - MTBLS385
Resolution: 75μm, 121x68

Description

179.0344 [M+H]+
PPM:15.9		 Homo sapiens esophagus DESI ()
LNTO22_1_4 - MTBLS385
Resolution: 17μm, 82x80

Description

179.0347 [M+H]+
PPM:14.3		 Homo sapiens esophagus DESI ()
TO42T - MTBLS385
Resolution: 17μm, 69x81

Description

179.0358 [M+H]+
PPM:8.1		 Homo sapiens esophagus DESI ()
LNTO22_1_9 - MTBLS385
Resolution: 75μm, 89x74

Description

179.0346 [M+H]+
PPM:14.8		 Homo sapiens esophagus DESI ()
LNTO26_7_1 - MTBLS385
Resolution: 17μm, 75x74

Description

179.0355 [M+H]+
PPM:9.8		 Homo sapiens esophagus DESI ()
LNTO26_7_2 - MTBLS385
Resolution: 17μm, 135x101

Description

179.0346 [M+H]+
PPM:14.8		 Homo sapiens esophagus DESI ()
LNTO26_7_3 - MTBLS385
Resolution: 75μm, 82x88

Description

179.0343 [M+H]+
PPM:16.5		 Homo sapiens esophagus DESI ()
TO40T - MTBLS385
Resolution: 17μm, 82x74

Description

179.0344 [M+H]+
PPM:15.9		 Homo sapiens esophagus DESI ()
TO31T - MTBLS385
Resolution: 75μm, 56x54

Description

179.0347 [M+H]+
PPM:14.3		 Homo sapiens esophagus DESI ()
TO29T - MTBLS385
Resolution: 75μm, 56x48

Description

161.024 [M+H-H2O]+
PPM:16.7		 Homo sapiens esophagus DESI ()
LNTO22_1_5 - MTBLS385
Resolution: 75μm, 135x94

Description

179.0366 [M+H]+
PPM:3.7		 Homo sapiens esophagus DESI ()
LNTO22_1_5 - MTBLS385
Resolution: 75μm, 135x94

Description

179.0348 [M+H]+
PPM:13.7		 Homo sapiens esophagus DESI ()
LNTO22_1_7 - MTBLS385
Resolution: 75μm, 69x54

Description

161.0238 [M+H-H2O]+
PPM:17.9		 Homo sapiens esophagus DESI ()
LNTO22_1_8 - MTBLS385
Resolution: 75μm, 69x61

Description

179.0356 [M+H]+
PPM:9.2		 Homo sapiens esophagus DESI ()
LNTO22_1_8 - MTBLS385
Resolution: 75μm, 69x61

Description

161.0243 [M+H-H2O]+
PPM:14.8		 Homo sapiens esophagus DESI ()
LNTO22_2_2 - MTBLS385
Resolution: 75μm, 135x94

Description

179.0346 [M+H]+
PPM:14.8		 Homo sapiens esophagus DESI ()
LNTO26_16_1 - MTBLS385
Resolution: 75μm, 95x88

Description

161.0236 [M+H-H2O]+
PPM:19.2		 Homo sapiens esophagus DESI ()
LNTO30_7_2 - MTBLS385
Resolution: 75μm, 82x68

Description

179.0349 [M+H]+
PPM:13.2		 Homo sapiens esophagus DESI ()
LNTO30_7_2 - MTBLS385
Resolution: 75μm, 82x68

Description


2,3-Dihydroxy-5-methylthio-4-pentenoic acid (DMTPA) is a hydroxy fatty acid with a thioenolether group. DMTPA was previously an unknown potential plasma biomarker for glomerular filtration rate (GFR) but its structure has since been elucidated (PMID: 29578721). DMTPA is possibly involved in the methionine salvage pathway (MSP) and may potentially be synthesized from methylthioadenosine (MTA). MTA is a byproduct of S-adenosylmethionine (SAM) during polyamine biosynthesis.