M/Z: 780.4439

Hit 2 annotations: Digoxin_[M-H2O+NH4]+; Cyclosomatostatin_[M+H]+

在BioDeep NovoCell知识数据库中，参考离子总共被划分为4个级别。

Confirmed: 这个参考离子已经通过手动审计得到确认和验证。
Reliable: 这个参考离子可能在特定的解剖组织环境中高度保守。
Unreliable: 这个参考离子具有较高的排名价值，但缺乏可重复性。
Unavailable: 由于排名价值低且缺乏可重复性，这个参考离子不应用于注释。

Found 11 Reference Ions Near m/z 780.4439

NovoCell ID	m/z	Mass Window	Metabolite	Ranking	Anatomy Context
MSI_000053274 Unreliable	780.4484	780.4484 ~ 780.4484 MzDiff: `none`	Cyclosomatostatin (BioDeep_00000177784) Formula: C44H57N7O6 (779.437)	2.74 (100%)	DESI [NOVOCELL:BACKGROUND] blank
MSI_000060305 Unreliable	780.4429	780.4427 ~ 780.443 MzDiff: `0.9 ppm`	Cyclosomatostatin (BioDeep_00000177784) Formula: C44H57N7O6 (779.437)	3.92 (100%)	Mus musculus [UBERON:0002421] hippocampal formation
MSI_000061359 Unavailable	780.4445	780.4445 ~ 780.4447 MzDiff: `0.7 ppm`	Cyclosomatostatin (BioDeep_00000177784) Formula: C44H57N7O6 (779.437)	-0.88 (100%)	Mus musculus [UBERON:0000956] cerebral cortex
MSI_000062615 Unreliable	780.4446	780.4445 ~ 780.4447 MzDiff: `0.7 ppm`	Cyclosomatostatin (BioDeep_00000177784) Formula: C44H57N7O6 (779.437)	3.64 (100%)	Mus musculus [UBERON:0002421] hippocampal formation
MSI_000002645 Unavailable	780.4424	780.4424 ~ 780.4424 MzDiff: `none`	Digoxin (BioDeep_00000000332) Formula: C41H64O14 (780.4296)	-0.05 (100%)	Rattus norvegicus [UBERON:0001950] neocortex
MSI_000003459 Unavailable	780.4424	780.4424 ~ 780.4424 MzDiff: `none`	Digoxin (BioDeep_00000000332) Formula: C41H64O14 (780.4296)	-0.46 (100%)	Rattus norvegicus [UBERON:0002037] cerebellum
MSI_000004912 Unreliable	780.4424	780.4424 ~ 780.4424 MzDiff: `none`	Digoxin (BioDeep_00000000332) Formula: C41H64O14 (780.4296)	0.38 (100%)	Rattus norvegicus [UBERON:0002298] brainstem
MSI_000005744 Unavailable	780.4424	780.4424 ~ 780.4424 MzDiff: `none`	Digoxin (BioDeep_00000000332) Formula: C41H64O14 (780.4296)	-0.55 (100%)	Rattus norvegicus [UBERON:0002435] striatum
MSI_000025079 Unreliable	780.4439	780.4439 ~ 780.4439 MzDiff: `none`	Digoxin (BioDeep_00000000332) Formula: C41H64O14 (780.4296)	1.73 (100%)	Mus musculus [UBERON:0004269] upper arm connective tissue
MSI_000059307 Unavailable	780.4429	780.4429 ~ 780.4429 MzDiff: `none`	Cyclosomatostatin (BioDeep_00000177784) Formula: C44H57N7O6 (779.437)	-1.15 (100%)	Mus musculus [UBERON:0001950] neocortex
MSI_000059704 Unreliable	780.4429	780.4429 ~ 780.4429 MzDiff: `none`	Cyclosomatostatin (BioDeep_00000177784) Formula: C44H57N7O6 (779.437)	0.49 (100%)	Mus musculus [UBERON:0002298] brainstem

Found 12 Sample Hits

Metabolite	Species	Sample
Digoxin Formula: C41H64O14 (780.4296) Adducts: [M-H2O+NH4]+ (Ppm: 13.4)	Rattus norvegicus (Brain)	Spectroswiss - sol_2x_br_2 Resolution: 17μm, 488x193 Description
Digoxin Formula: C41H64O14 (780.4296) Adducts: [M-H2O+NH4]+ (Ppm: 11.5)	Mus musculus (Left upper arm)	357_l_total ion count Resolution: 50μm, 97x131 Description Diseased
Cyclosomatostatin Formula: C44H57N7O6 (779.437) Adducts: [M+H]+ (Ppm: 5)	Mus musculus (Lung)	image5 Resolution: 40μm, 163x183 Description Supplementary Figure S8. MALDI-MSI data of mouse lung tissue administered with D9-choline and U 13C-DPPC–containing Poractant alfa surfactant (labels administered 18 h prior to sacrifice). Ion images of (a) m/z 796.6856 ([U13C-DPPC+Na]+), (b) m/z 756.5154 [PC32:0+Na]+ and (c) m/z 765.6079 ([D9-PC32:0+Na]+). (d) Overlay image of [U13C-DPPC+Na]+ (red) and [D9-PC32:0+Na]+ (green). Parts per million (ppm) mass errors are indicated in parentheses. All images were visualised using totalion-current normalisation and using hotspot removal (high quantile = 99%). DPPC = PC16:0/16:0.
Cyclosomatostatin Formula: C44H57N7O6 (779.437) Adducts: [M+H]+ (Ppm: 5.3)	Homo sapiens (colorectal adenocarcinoma)	80TopL, 50TopR, 70BottomL, 60BottomR-profile Resolution: 17μm, 137x136 Description The human colorectal adenocarcinoma sample was excised during a surgical operation performed at the Imperial College Healthcare NHS Trust. The sample and procedures were carried out in accordance with ethical approval (14/EE/0024).
Cyclosomatostatin Formula: C44H57N7O6 (779.437) Adducts: [M+H]+ (Ppm: 5.9)	Homo sapiens (NA)	160TopL,130TopR,150BottomL,140BottomR-profile Resolution: 17μm, 142x136 Description
m/z_780.4396 Formula: - (n/a) Adducts: (Ppm: 0)	Homo sapiens (esophagus)	LNTO22_2_1 Resolution: 75μm, 89x88 Description
Cyclosomatostatin Formula: C44H57N7O6 (779.437) Adducts: [M+H]+ (Ppm: 0.5)	Mus musculus (brain)	Brain01_Bregma1-42_02_centroid Resolution: 17μm, 434x258 Description
Cyclosomatostatin Formula: C44H57N7O6 (779.437) Adducts: [M+H]+ (Ppm: 0.3)	Mus musculus (brain)	Brain01_Bregma1-42_01_centroid Resolution: 17μm, 447x118 Description
Cyclosomatostatin Formula: C44H57N7O6 (779.437) Adducts: [M+H]+ (Ppm: 1.6)	Mus musculus (brain)	Brain02_Bregma1-42_03 Resolution: 17μm, 483x403 Description
Cyclosomatostatin Formula: C44H57N7O6 (779.437) Adducts: [M+H]+ (Ppm: 2.2)	Mus musculus (brain)	Brain02_Bregma-3-88 Resolution: 17μm, 288x282 Description
Cyclosomatostatin Formula: C44H57N7O6 (779.437) Adducts: [M+H]+ (Ppm: 2)	Mus musculus (brain)	Brain02_Bregma-1-46 Resolution: 17μm, 294x399 Description
Digoxin Formula: C41H64O14 (780.4296) Adducts: [M-H2O+NH4]+ (Ppm: 13.4)	Drosophila melanogaster (brain)	Drosophila18 Resolution: 5μm, 686x685 Description Sample information Organism: Drosophila melanogaster Organism part: Brain Condition: Healthy Sample preparation Sample stabilisation: Frozen Tissue modification: Frozen MALDI matrix: 2,5-dihydroxybenzoic acid (DHB) MALDI matrix application: TM sprayer Solvent: Aceton/water MS analysis Polarity: Positive Ionisation source: Prototype Analyzer: Orbitrap Pixel size: 5μm × 5μm Annotation settings m/z tolerance (ppm): 3 Analysis version: Original MSM Pixel count: 469910 Imzml file size: 696.23 MB Ibd file size: 814.11 MB