M/Z: 765.4951
Hit 3 annotations: PA(18:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4))_[M+H]+; PE(15:0/5-iso PGF2VI)_[M+NH4]+; Ginsenoside Rg1_[M+H-2H2O]+
- Confirmed: 这个参考离子已经通过手动审计得到确认和验证。
- Reliable: 这个参考离子可能在特定的解剖组织环境中高度保守。
- Unreliable: 这个参考离子具有较高的排名价值，但缺乏可重复性。
- Unavailable: 由于排名价值低且缺乏可重复性，这个参考离子不应用于注释。
Found 11 Reference Ions Near m/z 765.4951
| NovoCell ID | m/z | Mass Window | Metabolite | Ranking | Anatomy Context |
|---|---|---|---|---|---|
| MSI_000061287 Unavailable | 765.4854 | 765.4852 ~ 765.4858 MzDiff: 2.3 ppm |
PA(19:2(10Z,13Z)/PGJ2) (BioDeep_00000189540) Formula: C42H69O10P (764.4628) |
-0.22 (67%) | Mus musculus [UBERON:0000956] cerebral cortex |
| MSI_000026359 Unreliable | 765.4855 | 765.4851 ~ 765.4859 MzDiff: 3.5 ppm |
PE(14:1(9Z)/22:6(5Z,8E,10Z,13Z,15E,19Z)-2OH(7S, 17S)) (BioDeep_00000185738) Formula: C41H68NO10P (765.4581) |
3.1 (50%) | Mus musculus [UBERON:0002048] lung |
| MSI_000062645 Unreliable | 765.4855 | 765.4852 ~ 765.4858 MzDiff: 2.3 ppm |
(1R,4R,4'R,5S,5'S,6R,6'S,7R,9R,11R,12R,13S,14S)-12-[(3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-4-ethyl-5,5',6,11-tetrahydroxy-4'-methoxy-4',5,6',7,9,11,13-heptamethylspiro[3,15,17-trioxabicyclo[12.4.0]octadecane-16,2'-oxane]-2,8-dione (BioDeep_00000171576) Formula: C37H65NO14 (747.4405) |
2.9 (50%) | Mus musculus [UBERON:0002421] hippocampal formation |
| MSI_000021290 Unreliable | 765.4932 | 765.4932 ~ 765.4932 MzDiff: none |
PA(18:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4)) (BioDeep_00000188649) Formula: C43H73O9P (764.4992) |
1.29 (100%) | Mus musculus [UBERON:0001499] muscle of arm |
| MSI_000062248 Unavailable | 765.4858 | 765.4858 ~ 765.4858 MzDiff: none |
(1R,4R,4'R,5S,5'S,6R,6'S,7R,9R,11R,12R,13S,14S)-12-[(3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-4-ethyl-5,5',6,11-tetrahydroxy-4'-methoxy-4',5,6',7,9,11,13-heptamethylspiro[3,15,17-trioxabicyclo[12.4.0]octadecane-16,2'-oxane]-2,8-dione (BioDeep_00000171576) Formula: C37H65NO14 (747.4405) |
-0.18 (100%) | Mus musculus [UBERON:0001950] neocortex |
| MSI_000029897 Unavailable | 765.4928 | 765.4928 ~ 765.4928 MzDiff: none |
PA(18:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4)) (BioDeep_00000188649) Formula: C43H73O9P (764.4992) |
-0.33 (100%) | Macropus giganteus [UBERON:0002336] corpus callosum |
| MSI_000030494 Unreliable | 765.4928 | 765.4928 ~ 765.4928 MzDiff: none |
PA(18:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4)) (BioDeep_00000188649) Formula: C43H73O9P (764.4992) |
1.67 (100%) | Macropus giganteus [UBERON:0003027] cingulate cortex |
| MSI_000031363 Unreliable | 765.4928 | 765.4928 ~ 765.4928 MzDiff: none |
PA(18:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4)) (BioDeep_00000188649) Formula: C43H73O9P (764.4992) |
1.11 (100%) | Macropus giganteus [UBERON:0006093] precuneus cortex |
| MSI_000061517 Unavailable | 765.4996 | 765.4996 ~ 765.4996 MzDiff: none |
PS(14:0/18:1(12Z)-2OH(9,10)) (BioDeep_00000205849) Formula: C38H72NO12P (765.4792) |
-0.34 (100%) | Mus musculus [UBERON:0000956] cerebral cortex |
| MSI_000062484 Unavailable | 765.4996 | 765.4996 ~ 765.4996 MzDiff: none |
PS(14:0/18:1(12Z)-2OH(9,10)) (BioDeep_00000205849) Formula: C38H72NO12P (765.4792) |
-0.38 (100%) | Mus musculus [UBERON:0001950] neocortex |
| MSI_000062882 Unavailable | 765.4996 | 765.4996 ~ 765.4996 MzDiff: none |
PS(14:0/18:1(12Z)-2OH(9,10)) (BioDeep_00000205849) Formula: C38H72NO12P (765.4792) |
-0.4 (100%) | Mus musculus [UBERON:0002421] hippocampal formation |
Found 5 Sample Hits
| Metabolite | Species | Sample | |
|---|---|---|---|
| PA(18:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4)) Formula: C43H73O9P (764.4992) Adducts: [M+H]+ (Ppm: 14.9) |
Rattus norvegicus (Epididymis) |
epik_dhb_head_ito01_03Resolution: 17μm, 159x110
|
|
| PE(15:0/5-iso PGF2VI) Formula: C38H70NO11P (747.4686) Adducts: [M+NH4]+ (Ppm: 18.7) |
Mus musculus (Lung) |
image1Resolution: 40μm, 187x165
Fig. 2 MALDI-MSI data from the same mouse lung tissue analyzed in Fig. 1. A: Optical image of the post-MSI, H&E-stained tissue section. B–D, F–G: Ion images of (B) m/z 796.6855 ([U13C-DPPC+Na]+), (C) m/z 756.5514 ([PC32:0+Na]+), (D) m/z 765.6079 ([D9-PC32:0+Na]+), (F) m/z 754.5359 ([PC32:1+Na]+), and (G) m/z 763.5923 ([D9-PC32:1+Na]+). E, H: Ratio images of (E) [D9-PC32:0+Na]+:[PC32:0+Na]+ and (H) [D9-PC32:1+Na]+:[PC32:1+Na]+. Part-per-million (ppm) mass errors are indicated in parentheses. All images were visualized using total-ion-current normalization and using hotspot removal (high quantile = 99%). DPPC = PC16:0/16:0. U13C-DPPC, universally 13C-labeled dipalmitoyl PC; PC, phosphatidylcholine; MSI, mass spectrometry imaging; H&E, hematoxylin and eosin.
Fig 1-3, Fig S1-S3, S5 |
|
| PA(18:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4)) Formula: C43H73O9P (764.4992) Adducts: [M+H]+ (Ppm: 17.3) |
Mus musculus (Left upper arm) |
357_l_total ion countResolution: 50μm, 97x131
Diseased |
|
| Ginsenoside Rg1 Formula: C42H72O14 (800.4922) Adducts: [M+H-2H2O]+ (Ppm: 8.8) |
Mus musculus (Lung) |
image5Resolution: 40μm, 163x183
Supplementary Figure S8. MALDI-MSI data of mouse lung tissue administered with D9-choline and
U 13C-DPPC–containing Poractant alfa surfactant (labels administered 18 h prior to sacrifice). Ion
images of (a) m/z 796.6856 ([U13C-DPPC+Na]+), (b) m/z 756.5154 [PC32:0+Na]+ and (c) m/z 765.6079
([D9-PC32:0+Na]+). (d) Overlay image of [U13C-DPPC+Na]+ (red) and [D9-PC32:0+Na]+ (green).
Parts per million (ppm) mass errors are indicated in parentheses. All images were visualised using totalion-current normalisation and using hotspot removal (high quantile = 99%). DPPC = PC16:0/16:0. |
|
| PA(18:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4)) Formula: C43H73O9P (764.4992) Adducts: [M+H]+ (Ppm: 17.9) |
Macropus giganteus (Brain) |
170321_kangaroobrain-dan3-pos_maxof50.0_med1Resolution: 50μm, 81x50
Sample information
Organism: Macropus giganteus (kangaroo)
Organism part: Brain
Condition: Wildtype
Sample growth conditions: Wild |
|
