M/Z: 725.3871
Hit 5 annotations: (7e)-12-(hydroxymethyl)-22-{[(3z,4z)-4-(5-hydroxypentan-2-ylidene)-2-(2-methylpropyl)oxolan-3-ylidene]methyl}-8,12-dimethyl-17-(2-methylpropyl)-10,14,19,24-tetraoxa-23,25-diazatetracyclo[19.2.1.1²,⁵.0⁹,¹³]pentacosa-1(23),2,4,7-tetraene-11,15,18-trione_[M+H]+; 19-Hydroxydeacetylnomilinic acid 17-beta-D-glucopyranoside_[M+K]+; PG(i-12:0/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15))_[M+H-2H2O]+; Dalargin_[M]+; PA(13:0/PGE2)_[M+Na]+
- Confirmed: 这个参考离子已经通过手动审计得到确认和验证。
- Reliable: 这个参考离子可能在特定的解剖组织环境中高度保守。
- Unreliable: 这个参考离子具有较高的排名价值，但缺乏可重复性。
- Unavailable: 由于排名价值低且缺乏可重复性，这个参考离子不应用于注释。
Found 12 Reference Ions Near m/z 725.3871
| NovoCell ID | m/z | Mass Window | Metabolite | Ranking | Anatomy Context |
|---|---|---|---|---|---|
| MSI_000061208 Reliable | 725.3918 | 725.3918 ~ 725.3918 MzDiff: 0.1 ppm |
Dalargin (BioDeep_00000177934) Formula: C35H51N9O8 (725.386) |
2.39 (80%) | Mus musculus [UBERON:0000956] cerebral cortex |
| MSI_000058172 Reliable | 725.3897 | 725.3896 ~ 725.3899 MzDiff: 1.4 ppm |
PA(13:0/PGE2) (BioDeep_00000187870) Formula: C36H63O11P (702.4108) |
4.44 (67%) | Homo sapiens [UBERON:0001043] esophagus |
| MSI_000021677 Unreliable | 725.3934 | 725.3934 ~ 725.3934 MzDiff: none |
PG(i-12:0/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15)) (BioDeep_00000196115) Formula: C38H65O13P (760.4163) |
0.74 (100%) | Mus musculus [UBERON:0001499] muscle of arm |
| MSI_000002454 Unreliable | 725.3921 | 725.3921 ~ 725.3921 MzDiff: none |
(7e)-12-(hydroxymethyl)-22-{[(3z,4z)-4-(5-hydroxypentan-2-ylidene)-2-(2-methylpropyl)oxolan-3-ylidene]methyl}-8,12-dimethyl-17-(2-methylpropyl)-10,14,19,24-tetraoxa-23,25-diazatetracyclo[19.2.1.1²,⁵.0⁹,¹³]pentacosa-1(23),2,4,7-tetraene-11,15,18-trione (BioDeep_00002143257) Formula: C40H56N2O10 (724.3935) |
1.17 (100%) | Rattus norvegicus [UBERON:0001950] neocortex |
| MSI_000003147 Unreliable | 725.3921 | 725.3921 ~ 725.3921 MzDiff: none |
(7e)-12-(hydroxymethyl)-22-{[(3z,4z)-4-(5-hydroxypentan-2-ylidene)-2-(2-methylpropyl)oxolan-3-ylidene]methyl}-8,12-dimethyl-17-(2-methylpropyl)-10,14,19,24-tetraoxa-23,25-diazatetracyclo[19.2.1.1²,⁵.0⁹,¹³]pentacosa-1(23),2,4,7-tetraene-11,15,18-trione (BioDeep_00002143257) Formula: C40H56N2O10 (724.3935) |
1.74 (100%) | Rattus norvegicus [UBERON:0002037] cerebellum |
| MSI_000005295 Unavailable | 725.3921 | 725.3921 ~ 725.3921 MzDiff: none |
(7e)-12-(hydroxymethyl)-22-{[(3z,4z)-4-(5-hydroxypentan-2-ylidene)-2-(2-methylpropyl)oxolan-3-ylidene]methyl}-8,12-dimethyl-17-(2-methylpropyl)-10,14,19,24-tetraoxa-23,25-diazatetracyclo[19.2.1.1²,⁵.0⁹,¹³]pentacosa-1(23),2,4,7-tetraene-11,15,18-trione (BioDeep_00002143257) Formula: C40H56N2O10 (724.3935) |
-0.87 (100%) | Rattus norvegicus [UBERON:0002298] brainstem |
| MSI_000005651 Unavailable | 725.3921 | 725.3921 ~ 725.3921 MzDiff: none |
(7e)-12-(hydroxymethyl)-22-{[(3z,4z)-4-(5-hydroxypentan-2-ylidene)-2-(2-methylpropyl)oxolan-3-ylidene]methyl}-8,12-dimethyl-17-(2-methylpropyl)-10,14,19,24-tetraoxa-23,25-diazatetracyclo[19.2.1.1²,⁵.0⁹,¹³]pentacosa-1(23),2,4,7-tetraene-11,15,18-trione (BioDeep_00002143257) Formula: C40H56N2O10 (724.3935) |
-0.38 (100%) | Rattus norvegicus [UBERON:0002435] striatum |
| MSI_000023264 Unreliable | 725.3934 | 725.3934 ~ 725.3934 MzDiff: none |
PG(i-12:0/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15)) (BioDeep_00000196115) Formula: C38H65O13P (760.4163) |
0.41 (100%) | Mus musculus [UBERON:0004250] upper arm bone |
| MSI_000056123 Unavailable | 725.3906 | 725.3906 ~ 725.3906 MzDiff: none |
Not Annotated | -0.55 (0%) | Homo sapiens [UBERON:0007779] transudate |
| MSI_000058687 Unreliable | 725.3918 | 725.3918 ~ 725.3918 MzDiff: none |
Dalargin (BioDeep_00000177934) Formula: C35H51N9O8 (725.386) |
1.55 (100%) | Mus musculus [UBERON:0001950] neocortex |
| MSI_000060060 Unavailable | 725.3923 | 725.3923 ~ 725.3923 MzDiff: none |
Dalargin (BioDeep_00000177934) Formula: C35H51N9O8 (725.386) |
-0.88 (100%) | Mus musculus [UBERON:0002298] brainstem |
| MSI_000060483 Unavailable | 725.3923 | 725.3923 ~ 725.3923 MzDiff: none |
Dalargin (BioDeep_00000177934) Formula: C35H51N9O8 (725.386) |
-0.2 (100%) | Mus musculus [UBERON:0002421] hippocampal formation |
Found 11 Sample Hits
| Metabolite | Species | Sample | |
|---|---|---|---|
| (7e)-12-(hydroxymethyl)-22-{[(3z,4z)-4-(5-hydroxypentan-2-ylidene)-2-(2-methylpropyl)oxolan-3-ylidene]methyl}-8,12-dimethyl-17-(2-methylpropyl)-10,14,19,24-tetraoxa-23,25-diazatetracyclo[19.2.1.1²,⁵.0⁹,¹³]pentacosa-1(23),2,4,7-tetraene-11,15,18-trione Formula: C40H56N2O10 (724.3935) Adducts: [M+H]+ (Ppm: 11.9) |
Rattus norvegicus (Brain) |
Spectroswiss - sol_2x_br_2Resolution: 17μm, 488x193
|
|
| 19-Hydroxydeacetylnomilinic acid 17-beta-D-glucopyranoside Formula: C32H46O16 (686.2786) Adducts: [M+K]+ (Ppm: 14.9) |
Mus musculus (Lung) |
image1Resolution: 40μm, 187x165
Fig. 2 MALDI-MSI data from the same mouse lung tissue analyzed in Fig. 1. A: Optical image of the post-MSI, H&E-stained tissue section. B–D, F–G: Ion images of (B) m/z 796.6855 ([U13C-DPPC+Na]+), (C) m/z 756.5514 ([PC32:0+Na]+), (D) m/z 765.6079 ([D9-PC32:0+Na]+), (F) m/z 754.5359 ([PC32:1+Na]+), and (G) m/z 763.5923 ([D9-PC32:1+Na]+). E, H: Ratio images of (E) [D9-PC32:0+Na]+:[PC32:0+Na]+ and (H) [D9-PC32:1+Na]+:[PC32:1+Na]+. Part-per-million (ppm) mass errors are indicated in parentheses. All images were visualized using total-ion-current normalization and using hotspot removal (high quantile = 99%). DPPC = PC16:0/16:0. U13C-DPPC, universally 13C-labeled dipalmitoyl PC; PC, phosphatidylcholine; MSI, mass spectrometry imaging; H&E, hematoxylin and eosin.
Fig 1-3, Fig S1-S3, S5 |
|
| PG(i-12:0/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15)) Formula: C38H65O13P (760.4163) Adducts: [M+H-2H2O]+ (Ppm: 12.4) |
Mus musculus (Left upper arm) |
357_l_total ion countResolution: 50μm, 97x131
Diseased |
|
| PG(i-12:0/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15)) Formula: C38H65O13P (760.4163) Adducts: [M+H-2H2O]+ (Ppm: 17) |
Homo sapiens (esophagus) |
LNTO22_1_3Resolution: 75μm, 121x68
|
|
| m/z_725.3906 Formula: - (n/a) Adducts: (Ppm: 0) |
Homo sapiens (esophagus) |
LNTO22_1_9Resolution: 75μm, 89x74
|
|
| m/z_725.3906 Formula: - (n/a) Adducts: (Ppm: 0) |
Homo sapiens (esophagus) |
LNTO26_7_2Resolution: 17μm, 135x101
|
|
| Dalargin Formula: C35H51N9O8 (725.386) Adducts: [M]+ (Ppm: 6.5) |
Homo sapiens (esophagus) |
LNTO22_1_5Resolution: 75μm, 135x94
|
|
| Dalargin Formula: C35H51N9O8 (725.386) Adducts: [M]+ (Ppm: 6.4) |
Homo sapiens (esophagus) |
LNTO22_1_7Resolution: 75μm, 69x54
|
|
| PA(13:0/PGE2) Formula: C36H63O11P (702.4108) Adducts: [M+Na]+ (Ppm: 13.9) |
Homo sapiens (esophagus) |
LNTO22_1_8Resolution: 75μm, 69x61
|
|
| PA(13:0/PGE2) Formula: C36H63O11P (702.4108) Adducts: [M+Na]+ (Ppm: 14.3) |
Homo sapiens (esophagus) |
LNTO22_2_1Resolution: 75μm, 89x88
|
|
| Dalargin Formula: C35H51N9O8 (725.386) Adducts: [M]+ (Ppm: 5.9) |
Homo sapiens (esophagus) |
LNTO26_16_1Resolution: 75μm, 95x88
|
|
