- Confirmed: 这个参考离子已经通过手动审计得到确认和验证。
- Reliable: 这个参考离子可能在特定的解剖组织环境中高度保守。
- Unreliable: 这个参考离子具有较高的排名价值，但缺乏可重复性。
- Unavailable: 由于排名价值低且缺乏可重复性，这个参考离子不应用于注释。
Found 6 Reference Ions Near m/z 540.2269
| NovoCell ID | m/z | Mass Window | Metabolite | Ranking | Anatomy Context |
|---|---|---|---|---|---|
| MSI_000024640 Unreliable | 540.2266 | 540.2266 ~ 540.2266 MzDiff: none |
ceritinib (BioDeep_00000177165) Formula: C28H36ClN5O3S (557.2227) |
1.77 (100%) | Mus musculus [UBERON:0004269] upper arm connective tissue |
| MSI_000003025 Unavailable | 540.2269 | 540.2269 ~ 540.2269 MzDiff: none |
(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide (BioDeep_00000017112) Formula: C30H32ClN7O2 (557.2306) |
-0.98 (100%) | Rattus norvegicus [UBERON:0001950] neocortex |
| MSI_000003687 Unavailable | 540.2269 | 540.2269 ~ 540.2269 MzDiff: none |
(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide (BioDeep_00000017112) Formula: C30H32ClN7O2 (557.2306) |
-1.17 (100%) | Rattus norvegicus [UBERON:0002037] cerebellum |
| MSI_000005221 Unavailable | 540.2269 | 540.2269 ~ 540.2269 MzDiff: none |
(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide (BioDeep_00000017112) Formula: C30H32ClN7O2 (557.2306) |
-0.74 (100%) | Rattus norvegicus [UBERON:0002298] brainstem |
| MSI_000005561 Unreliable | 540.2269 | 540.2269 ~ 540.2269 MzDiff: none |
(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide (BioDeep_00000017112) Formula: C30H32ClN7O2 (557.2306) |
0.77 (100%) | Rattus norvegicus [UBERON:0002435] striatum |
| MSI_000025896 Unreliable | 540.2345 | 540.2345 ~ 540.2345 MzDiff: none |
Icariside E5 (BioDeep_00000017589) Formula: C26H34O11 (522.2101) |
2.02 (100%) | Mus musculus [UBERON:0000913] interstitial fluid |
Found 3 Sample Hits
| Metabolite | Species | Sample | |
|---|---|---|---|
| (R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide Formula: C30H32ClN7O2 (557.2306) Adducts: [M+H-H2O]+ (Ppm: 1.3) |
Rattus norvegicus (Brain) |
Spectroswiss - sol_2x_br_2Resolution: 17μm, 488x193
|
|
| Icariside E5 Formula: C26H34O11 (522.2101) Adducts: [M+NH4]+ (Ppm: 17.4) |
Mus musculus (Lung) |
image1Resolution: 40μm, 187x165
Fig. 2 MALDI-MSI data from the same mouse lung tissue analyzed in Fig. 1. A: Optical image of the post-MSI, H&E-stained tissue section. B–D, F–G: Ion images of (B) m/z 796.6855 ([U13C-DPPC+Na]+), (C) m/z 756.5514 ([PC32:0+Na]+), (D) m/z 765.6079 ([D9-PC32:0+Na]+), (F) m/z 754.5359 ([PC32:1+Na]+), and (G) m/z 763.5923 ([D9-PC32:1+Na]+). E, H: Ratio images of (E) [D9-PC32:0+Na]+:[PC32:0+Na]+ and (H) [D9-PC32:1+Na]+:[PC32:1+Na]+. Part-per-million (ppm) mass errors are indicated in parentheses. All images were visualized using total-ion-current normalization and using hotspot removal (high quantile = 99%). DPPC = PC16:0/16:0. U13C-DPPC, universally 13C-labeled dipalmitoyl PC; PC, phosphatidylcholine; MSI, mass spectrometry imaging; H&E, hematoxylin and eosin.
Fig 1-3, Fig S1-S3, S5 |
|
| ceritinib Formula: C28H36ClN5O3S (557.2227) Adducts: [M+H-H2O]+ (Ppm: 13.3) |
Mus musculus (Left upper arm) |
357_l_total ion countResolution: 50μm, 97x131
Diseased |
|
