M/Z: 457.2811

Hit 1 annotations: Leukotriene E4_[M+NH4]+

在BioDeep NovoCell知识数据库中，参考离子总共被划分为4个级别。

Confirmed: 这个参考离子已经通过手动审计得到确认和验证。
Reliable: 这个参考离子可能在特定的解剖组织环境中高度保守。
Unreliable: 这个参考离子具有较高的排名价值，但缺乏可重复性。
Unavailable: 由于排名价值低且缺乏可重复性，这个参考离子不应用于注释。

Found 5 Reference Ions Near m/z 457.2811

NovoCell ID	m/z	Mass Window	Metabolite	Ranking	Anatomy Context
MSI_000025349 Unreliable	457.2711	457.2711 ~ 457.2712 MzDiff: `0.6 ppm`	Leukotriene E4 (BioDeep_00000006013) Formula: C23H37NO5S (439.2392)	2.75 (100%)	Mus musculus [UBERON:0000913] interstitial fluid
MSI_000002917 Unavailable	457.2746	457.2746 ~ 457.2746 MzDiff: `none`	Leukotriene E4 (BioDeep_00000006013) Formula: C23H37NO5S (439.2392)	-0.57 (100%)	Rattus norvegicus [UBERON:0001950] neocortex
MSI_000003466 Unavailable	457.2746	457.2746 ~ 457.2746 MzDiff: `none`	Leukotriene E4 (BioDeep_00000006013) Formula: C23H37NO5S (439.2392)	-0.47 (100%)	Rattus norvegicus [UBERON:0002037] cerebellum
MSI_000004986 Unavailable	457.2746	457.2746 ~ 457.2746 MzDiff: `none`	Leukotriene E4 (BioDeep_00000006013) Formula: C23H37NO5S (439.2392)	-0.3 (100%)	Rattus norvegicus [UBERON:0002298] brainstem
MSI_000005837 Unavailable	457.2746	457.2746 ~ 457.2746 MzDiff: `none`	Leukotriene E4 (BioDeep_00000006013) Formula: C23H37NO5S (439.2392)	-0.72 (100%)	Rattus norvegicus [UBERON:0002435] striatum

Found 2 Sample Hits

Metabolite	Species	Sample
Leukotriene E4 Formula: C23H37NO5S (439.2392) Adducts: [M+NH4]+ (Ppm: 4.9)	Mus musculus (Lung)	image1 Resolution: 40μm, 187x165 Description Fig. 2 MALDI-MSI data from the same mouse lung tissue analyzed in Fig. 1. A: Optical image of the post-MSI, H&E-stained tissue section. B–D, F–G: Ion images of (B) m/z 796.6855 ([U13C-DPPC+Na]+), (C) m/z 756.5514 ([PC32:0+Na]+), (D) m/z 765.6079 ([D9-PC32:0+Na]+), (F) m/z 754.5359 ([PC32:1+Na]+), and (G) m/z 763.5923 ([D9-PC32:1+Na]+). E, H: Ratio images of (E) [D9-PC32:0+Na]+:[PC32:0+Na]+ and (H) [D9-PC32:1+Na]+:[PC32:1+Na]+. Part-per-million (ppm) mass errors are indicated in parentheses. All images were visualized using total-ion-current normalization and using hotspot removal (high quantile = 99%). DPPC = PC16:0/16:0. U13C-DPPC, universally 13C-labeled dipalmitoyl PC; PC, phosphatidylcholine; MSI, mass spectrometry imaging; H&E, hematoxylin and eosin. Fig 1-3, Fig S1-S3, S5
Leukotriene E4 Formula: C23H37NO5S (439.2392) Adducts: [M+NH4]+ (Ppm: 17.6)	Homo sapiens (esophagus)	LNTO22_1_4 Resolution: 17μm, 82x80 Description

Metabolite

Species

Sample

Leukotriene E4

Formula: C23H37NO5S (439.2392)
Adducts: [M+NH4]+ (Ppm: 4.9)

Mus musculus (Lung)

image1

Resolution: 40μm, 187x165

Description

Fig. 2 MALDI-MSI data from the same mouse lung tissue analyzed in Fig. 1. A: Optical image of the post-MSI, H&E-stained tissue section. B–D, F–G: Ion images of (B) m/z 796.6855 ([U13C-DPPC+Na]+), (C) m/z 756.5514 ([PC32:0+Na]+), (D) m/z 765.6079 ([D9-PC32:0+Na]+), (F) m/z 754.5359 ([PC32:1+Na]+), and (G) m/z 763.5923 ([D9-PC32:1+Na]+). E, H: Ratio images of (E) [D9-PC32:0+Na]+:[PC32:0+Na]+ and (H) [D9-PC32:1+Na]+:[PC32:1+Na]+. Part-per-million (ppm) mass errors are indicated in parentheses. All images were visualized using total-ion-current normalization and using hotspot removal (high quantile = 99%). DPPC = PC16:0/16:0. U13C-DPPC, universally 13C-labeled dipalmitoyl PC; PC, phosphatidylcholine; MSI, mass spectrometry imaging; H&E, hematoxylin and eosin. Fig 1-3, Fig S1-S3, S5

Leukotriene E4

Formula: C23H37NO5S (439.2392)
Adducts: [M+NH4]+ (Ppm: 17.6)

Homo sapiens (esophagus)

LNTO22_1_4

Resolution: 17μm, 82x80

Description