M/Z: 405.0657

Hit 1 annotations: Iolopride_[M+H]+

在BioDeep NovoCell知识数据库中，参考离子总共被划分为4个级别。

Confirmed: 这个参考离子已经通过手动审计得到确认和验证。
Reliable: 这个参考离子可能在特定的解剖组织环境中高度保守。
Unreliable: 这个参考离子具有较高的排名价值，但缺乏可重复性。
Unavailable: 由于排名价值低且缺乏可重复性，这个参考离子不应用于注释。

Found 14 Reference Ions Near m/z 405.0657

NovoCell ID	m/z	Mass Window	Metabolite	Ranking	Anatomy Context
MSI_000017620 Reliable	405.0582	405.0581 ~ 405.0582 MzDiff: `0.1 ppm`	(-)-Amurensisin (BioDeep_00000602302) Formula: C22H16O10 (440.0743)	1.88 (100%)	Vitis vinifera [PO:0009087] mesocarp
MSI_000053604 Reliable	405.0566	405.0563 ~ 405.0569 MzDiff: `2.3 ppm`	(-)-Amurensisin (BioDeep_00000602302) Formula: C22H16O10 (440.0743)	7.62 (56%)	MALDI - CHCA [NOVOCELL:BACKGROUND] blank
MSI_000010009 Unreliable	405.0583	405.0583 ~ 405.0583 MzDiff: `0.2 ppm`	dCDP (BioDeep_00000002934) Formula: C9H15N3O10P2 (387.0233)	1.12 (100%)	Bathymodiolus [UBERON:0009120] gill filament
MSI_000026217 Unreliable	405.0568	405.0568 ~ 405.0569 MzDiff: `0.2 ppm`	dCDP (BioDeep_00000002934) Formula: C9H15N3O10P2 (387.0233)	1.81 (100%)	Mus musculus [UBERON:0000913] interstitial fluid
MSI_000011875 Unreliable	405.0583	405.0583 ~ 405.0583 MzDiff: `0.1 ppm`	dCDP (BioDeep_00000002934) Formula: C9H15N3O10P2 (387.0233)	0.15 (100%)	Bathymodiolus [UBERON:2000211] gill lamella
MSI_000017051 Unavailable	405.0582	405.0581 ~ 405.0582 MzDiff: `0.0 ppm`	(-)-Amurensisin (BioDeep_00000602302) Formula: C22H16O10 (440.0743)	-0.32 (100%)	Vitis vinifera [PO:0009086] endocarp
MSI_000055043 Unreliable	405.0575	405.0575 ~ 405.0575 MzDiff: `none`	dCDP (BioDeep_00000002934) Formula: C9H15N3O10P2 (387.0233)	1.56 (100%)	MALDI - DHB [NOVOCELL:BACKGROUND] blank
MSI_000012857 Unavailable	405.0562	405.0562 ~ 405.0562 MzDiff: `none`	dCDP (BioDeep_00000002934) Formula: C9H15N3O10P2 (387.0233)	-0.5 (100%)	Plant [PO:0005020] vascular bundle
MSI_000014072 Unavailable	405.0562	405.0562 ~ 405.0562 MzDiff: `none`	dCDP (BioDeep_00000002934) Formula: C9H15N3O10P2 (387.0233)	-0.29 (100%)	Plant [PO:0005417] phloem
MSI_000014946 Unavailable	405.0562	405.0562 ~ 405.0562 MzDiff: `none`	dCDP (BioDeep_00000002934) Formula: C9H15N3O10P2 (387.0233)	-0.5 (100%)	Plant [PO:0006036] root epidermis
MSI_000018358 Unreliable	405.0562	405.0562 ~ 405.0562 MzDiff: `none`	dCDP (BioDeep_00000002934) Formula: C9H15N3O10P2 (387.0233)	1.78 (100%)	Plant [PO:0020124] root stele
MSI_000019946 Unavailable	405.0562	405.0562 ~ 405.0562 MzDiff: `none`	dCDP (BioDeep_00000002934) Formula: C9H15N3O10P2 (387.0233)	-0.5 (100%)	Plant [PO:0025197] stele
MSI_000034010 Unreliable	405.0569	405.0569 ~ 405.0569 MzDiff: `none`	(2s,3r,4s,5s,6r)-2-[(5,7-dichloro-8-hydroxy-6-methylnaphthalen-1-yl)oxy]-6-(hydroxymethyl)oxane-3,4,5-triol (BioDeep_00002134995) Formula: C17H18Cl2O7 (404.043)	0.08 (100%)	Posidonia oceanica [PO:0005352] xylem
MSI_000037546 Unreliable	405.0576	405.0576 ~ 405.0576 MzDiff: `none`	(-)-Amurensisin (BioDeep_00000602302) Formula: C22H16O10 (440.0743)	1.1 (100%)	Posidonia oceanica [UBERON:0000329] hair root

Found 2 Sample Hits

Metabolite	Species	Sample
Iolopride Formula: C15H21IN2O3 (404.0597) Adducts: [M+H]+ (Ppm: 3.1)	Homo sapiens (Liver)	20171107_FIT4_DHBpos_p70_s50 Resolution: 50μm, 70x70 Description
Iolopride Formula: C15H21IN2O3 (404.0597) Adducts: [M+H]+ (Ppm: 10.8)	Mus musculus (Lung)	image2 Resolution: 40μm, 550x256 Description Supplementary Figure S6. Ion distribution images for (a) [PC36:4+Na]+ (m/z 804.5514) and (b) [PC38:6+Na]+ (m/z 828.5515) obtained from mouse lung tissue collected 6 h after administration of D9- choline and U13C-DPPC–containing CHF5633. Parts-per-million (ppm) mass errors are indicated in parentheses. (c) Magnification of the boxed region in (a) with selected bronchiolar regions outlined in white boxes. (d) The corresponding H&E-stained tissue section with the same selected bronchiolar regions outlined in black boxes. These data demonstrate the co-localisation of the polyunsaturated lipids PC36:4 and PC38:6 with the bronchiolar regions of the lung. All MSI images were visualised using total ion current normalisation and hotspot removal (high quantile = 99%).

Metabolite

Species

Sample

Iolopride

Formula: C15H21IN2O3 (404.0597)
Adducts: [M+H]+ (Ppm: 3.1)

Homo sapiens (Liver)

20171107_FIT4_DHBpos_p70_s50

Resolution: 50μm, 70x70

Description

Iolopride

Formula: C15H21IN2O3 (404.0597)
Adducts: [M+H]+ (Ppm: 10.8)

Mus musculus (Lung)

image2

Resolution: 40μm, 550x256

Description

Supplementary Figure S6. Ion distribution images for (a) [PC36:4+Na]+ (m/z 804.5514) and (b) [PC38:6+Na]+ (m/z 828.5515) obtained from mouse lung tissue collected 6 h after administration of D9- choline and U13C-DPPC–containing CHF5633. Parts-per-million (ppm) mass errors are indicated in parentheses. (c) Magnification of the boxed region in (a) with selected bronchiolar regions outlined in white boxes. (d) The corresponding H&E-stained tissue section with the same selected bronchiolar regions outlined in black boxes. These data demonstrate the co-localisation of the polyunsaturated lipids PC36:4 and PC38:6 with the bronchiolar regions of the lung. All MSI images were visualised using total ion current normalisation and hotspot removal (high quantile = 99%).