MSI_000065859

Unreliable

排名分数: 1.63
参考来源: Homo sapiens (UBERON:0007779: transudate)

M/z: 310.0448
Mass Window: 310.0448 ~ 310.0449 (0.4 ppm)

参考注释

Carboxyphosphamide_[M+NH4]+ (BioDeep_00000006565)
3-({amino[bis(2-chloroethyl)amino]phosphoryl}oxy)propanoic acid

Formula: C7H15Cl2N2O4P (292.014646)
SMILES: C(COP(=O)(N)N(CCCl)CCCl)C(=O)O

In contrast to previous adult studies on urinary metabolites, plasma carboxyphosphamide concentrations did not support the existence of polymorphic metabolism. Plasma concentrations of dechlorethylcyclophosphamide and carboxyphosphamide were correlated in individual patients, suggesting that the activity of both aldehyde dehydrogenase and cytochrome P450 enzyme(s) determine carboxyphosphamide production in vivo. (PMID: 7850793) Detoxification of cyclophosphamide is effected, in part, by hepatic class 1 aldehyde dehydrogenase (ALDH-1)-catalyzed oxidation of aldophosphamide, a pivotal aldehyde intermediate, to the nontoxic metabolite, carboxyphosphamide. (PMID: 9394035) A key finding was the detection of a metabolite, most likely carboxyphosphamide, that is formed only by cytosols from cells expressing either class 3 or class 1 ALDH. (PMID: 8662659) D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D010752 - Phosphoramide Mustards