MSI_000065133

Reliable

排名分数: 5.92
参考来源: Homo sapiens (UBERON:0001155: colon)

M/z: 279.0389
Mass Window: 279.0387 ~ 279.039 (1.0 ppm)

参考注释

Alcophosphamide_[M+H]+ (BioDeep_00000011259)
3-({amino[bis(2-chloroethyl)amino]phosphoryl}oxy)propan-1-ol

Formula: C7H17Cl2N2O3P (278.0353802)
SMILES: C(CO)COP(=O)(N)N(CCCl)CCCl

Detoxification of cyclophosphamide is effected, in part, by hepatic class 1 aldehyde dehydrogenase (ALDH-1)-catalyzed oxidation of aldophosphamide, a pivotal aldehyde intermediate, to the nontoxic metabolite, carboxyphosphamide. Detoxification of aldophosphamide may also be effected by enzymes, viz. Thus, NAD-linked oxidation and NADPH-linked reduction of aldophosphamide catalyzed by relevant erythrocyte enzymes were quantified. (PMID: 9394035) It has already been demonstrated that horse liver alcohol dehydrogenase catalyzes the reduction of aldophosphamide to alcophosphamide. (PMID: 8216347) D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D010752 - Phosphoramide Mustards