MSI_000058012

Reliable

排名分数: 6.61
参考来源: DESI (NOVOCELL:BACKGROUND: blank)

M/z: 300.2054
Mass Window: 300.2051 ~ 300.2057 (2.2 ppm)

参考注释

Butenafine_[M+H-H2O]+ (BioDeep_00000006655)
N-4-Tert-butylbenzyl-N-methyl-1-naphthalene methylamine hydrochloride

Formula: C23H27N (317.21433820000004)
SMILES: CN(CC1=CC=C(C=C1)C(C)(C)C)CC1=CC=CC2=CC=CC=C12

Butenafine is only found in individuals that have used or taken this drug. It is a synthetic benzylamine antifungal agent.Although the mechanism of action has not been fully established, it has been suggested that butenafine, like allylamines, interferes with sterol biosynthesis (especially ergosterol) by inhibiting squalene monooxygenase, an enzyme responsible for converting squalene to 2,3-oxydo squalene. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Blockage of squalene monooxygenase also leads to a subsequent accumulation of squalene. When a high concentration of squalene is reached, it is thought to have an effect of directly kill fungal cells. D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use D000890 - Anti-Infective Agents > D000935 - Antifungal Agents C254 - Anti-Infective Agent > C514 - Antifungal Agent