MSI_000054867

Unreliable

排名分数: 1.68
参考来源: MALDI - DHB (NOVOCELL:BACKGROUND: blank)

M/z: 636.0814
Mass Window: 636.0814 ~ 636.0814 (none)

参考注释

Lonafarnib_[M]+ (BioDeep_00000229516)
4-(2-{4-[(2R)-6,15-dibromo-13-chloro-4-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl]piperidin-1-yl}-2-oxoethyl)piperidine-1-carboxamide

Formula: C27H31Br2ClN4O2 (636.0502135999999)
SMILES: NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2C3=C(CCC4=C2C(Br)=CC(Cl)=C4)C=C(Br)C=N3)CC1

A - Alimentary tract and metabolism > A16 - Other alimentary tract and metabolism products > A16A - Other alimentary tract and metabolism products > A16AX - Various alimentary tract and metabolism products C471 - Enzyme Inhibitor > C2020 - Farnesyl Transferase Inhibitor D004791 - Enzyme Inhibitors Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.