MSI_000046487

Reliable

排名分数: 4.42
参考来源: Mus musculus (UBERON:0002107: liver)

M/z: 244.0114
Mass Window: 244.0114 ~ 244.0114 (none)

参考注释

Fasentin_[M+H-2H2O]+ (BioDeep_00000178987)
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide

Formula: C11H9ClF3NO2 (279.027388)
SMILES: CC(=O)CC(=O)NC1=CC(=C(Cl)C=C1)C(F)(F)F

Fasentin, a potent glucose uptake inhibitor, inhibits GLUT-1/GLUT-4 transporters. Fasentin preferentially inhibits GLUT4 (IC50=68 μM) over GLUT1. Fasentin is a death receptor stimuli (FAS) sensitizer and sensitizes cells to FAS-induced cell death. Fasentin is also a tumor necrosis factor (TNF) apoptosis-inducing ligand sensitizer. Fasentin blocks glucose uptake in cancer cell lines and has anti-angiogenic activity[1][2][3].