MSI_000035097

Unreliable

排名分数: 2.04
参考来源: Posidonia oceanica (PO:0006203: pericycle)

M/z: 261.1255
Mass Window: 261.1255 ~ 261.1255 (none)

参考注释

Maculosin_[M+H]+ (BioDeep_00000003847)
Cyclo(L-Pro-L-Tyr)

Formula: C14H16N2O3 (260.1160866)
SMILES: C1CC2C(=O)NC(C(=O)N2C1)CC3=CC=C(C=C3)O

A homodetic cyclic peptide that is a dipeptide composed of L-proline and L-tyrosine joined by peptide linkages. Maculosin is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication by Pseudomonas aeruginosa. Maculosin also acts as a signaling molecule regulating virulence gene expression in Lactobacillus reuteri. Maculosin shows antioxidant, anti-cancer and non-toxicity properties. Maculosin shows cytotoxic activity against the human liver cancer cell lines, with an IC50 of 48.90 μg/mL[1][2][3]. Maculosin is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication by Pseudomonas aeruginosa. Maculosin also acts as a signaling molecule regulating virulence gene expression in Lactobacillus reuteri. Maculosin shows antioxidant, anti-cancer and non-toxicity properties. Maculosin shows cytotoxic activity against the human liver cancer cell lines, with an IC50 of 48.90 μg/mL[1][2][3].