MSI_000033295

Unreliable

排名分数: 2.22
参考来源: Posidonia oceanica (PO:0005352: xylem)

M/z: 263.0848
Mass Window: 263.0848 ~ 263.0848 (none)

参考注释

Indirubin_[M+H]+ (BioDeep_00000229852)
(Z)-[2,3 inverted exclamation mark -Biindolinylidene]-2 inverted exclamation mark ,3-dione

Formula: C16H10N2O2 (262.074224)
SMILES: C1=CC=C2C(=C1)C(=C(N2)O)C3=NC4=CC=CC=C4C3=O

A member of the class of indolones that is 1,3-dihydro-2H-indol-2-one substituted by a 3-oxo-1,3-dihydro-2H-indol-2-ylidene group at position 3. It is the active component of Dang Gui Long Hui Wan, which has been used in traditional Chinese medicine to treat inflammatory diseases and chronic myeloid leukemia. Indirubin is under investigation in clinical trial NCT01735864 (Dosage Determination Trial for Indigo Naturalis Extract in Oil Ointment). Indirubin is a natural product found in Isatis tinctoria, Couroupita guianensis, and Calanthe discolor with data available. D000970 - Antineoplastic Agents D004396 - Coloring Agents Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia[1][2]. Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia[1][2].