MSI_000029012

Unreliable

排名分数: 0.03
参考来源: Macropus giganteus (UBERON:0001891: midbrain)

M/z: 299.1356
Mass Window: 299.1356 ~ 299.1356 (none)

参考注释

N-Desmethyl Olanzapine_[M+H]+ (BioDeep_00000054393)
5-methyl-8-(piperazin-1-yl)-4-thia-2,9-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3(7),5,8,10,12-hexaene

Formula: C16H18N4S (298.12521080000005)
SMILES: CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCNCC4

4-N-desmethylolanzapine is a metabolite of olanzapine. Olanzapine (trade name Zyprexa or in combination with fluoxetine Symbyax) is an atypical antipsychotic, approved by the FDA for the treatment of schizophrenia and bipolar disorder. Olanzapine is structurally similar to clozapine, but is classified as a thienobenzodiazepine. The olanzapine formulations are manufactured and marketed by the pharmaceutical company Eli Lilly and Company; the drug went generic in 2011. Sales of Zyprexa in 2008 were $2.2B in the US alone, and $4.7B in total. (Wikipedia)