MSI_000004223

Unreliable

排名分数: 0.87
参考来源: Homo sapiens (UBERON:0002107: liver)

M/z: 379.0442
Mass Window: 379.0442 ~ 379.0442 (none)

参考注释

6-Methylthiopurine 5'-monophosphate ribonucleotide_[M+H]+ (BioDeep_00000014808)
{[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylsulfanyl)-9H-purin-9-yl]oxolan-2-yl]methoxy}phosphonic acid

Formula: C11H15N4O7PS (378.03990500000003)
SMILES: CSC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O

6-Methylthiopurine 5-monophosphate ribonucleotide, also known as methylthioinosine-5-monophosphate or meTIMP, is a metabolite of mercaptopurine. Mercaptopurine (also called 6-mercaptopurine, 6-MP, or its brand name Purinethol) is an immunosuppressive drug. Mercaptopurine is in the thiopurine and antimetabolite family of medications (Wikipedia). MeTIMP produced from 6-thioinosine monophosphate (6-TIMP) by thiopurine methyltransferase (TPMT) is an active metabolite that can inhibit de novo purine biosynthesis. High concentration of meTIMP has been related to hepatotoxicity and myelotoxicity (PMID: 21311411).